A Greater Increase in Complement C5a Receptor 1 Level at Onset and a Smaller Decrease in Immunoglobulin G Level after Recovery in Severer Coronavirus Disease 2019 Patients: A New Analysis of Existing Data with a New Two-Tailed t-Test. [PDF]
Biology (Basel), 2023 Ishida T +7 more
europepmc +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis. [PDF]
Mol Ther, 2021 Sommerfeld O +11 more
europepmc +1 more source
The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song +6 more
wiley +1 more source
Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene. [PDF]
Noncoding RNA, 2022 Emblem Å +7 more
europepmc +1 more source
Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang +2 more
wiley +1 more source
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. [PDF]
Nat Commun, 2021 Nording H +26 more
europepmc +1 more source
Atherosclerotic Cardiovascular Disease and Cancer
Immunological Reviews, Volume 340, Issue 1, July 2026.ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) and cancer are increasingly recognized as interconnected diseases linked by shared immune mechanisms rather than merely overlapping risk factors. Common exposures such as smoking, obesity, diabetes, and dyslipidemia, together with aging and clonal hematopoiesis of indeterminate potential (CHIP ...
Anaïs Amend +4 more
wiley +1 more source
Inflammatory Stewardship—A Perspective for Active Management of Acute Inflammation
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Inflammatory stewardship frames inflammation as a manageable clinical domain requiring explicit strategy, governance, and feedback. It aligns diagnostics, risk stratification, biomarker interpretation, and immunomodulatory decisions across perioperative and critical‐care teams.
Lennart Finn Herrlich +2 more
wiley +1 more source