Results 111 to 120 of about 1,253,157 (246)

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész, Tamás Mészáros, Bálint A. Barta, Réka Facsko, Anna Szilasi, Tamás Bakos, Gergely T. Kozma, Attila B. Dobos, Béla Merkely, Tamás Radovits, János Szebeni   +13 more
wiley   +1 more source

SAT-302 INHIBITION OF COMPLEMENT C5A/C5A RECEPTOR 1 DECREASES RENAL INJURY IN DIABETIC KIDNEY DISEASE VIA METABOLIC REPROGRAMMING

, 2019
SAT-302 INHIBITION OF COMPLEMENT C5A/C5A RECEPTOR 1 DECREASES RENAL INJURY IN DIABETIC KIDNEY DISEASE VIA METABOLIC ...
Mark Ziemann (13101363), M Cooper (13279140), E Ekinci (13353156), P Meikle (13347036), SM TAN (15790796), R MacIsaac (13353159), T Woodruff (13353162), M Coughlan (13353165)   +7 more
core  

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg74

, 2002
The substantial variations in the responses of cells to the anaphylatoxin C5a and its desarginated form, C5adR74, suggest that more than one type of cell surface receptor for these ligands might exist. However, only a single receptor for C5a and C5adR74,
Monk, Peter N., Peter N. Monk, Stuart A. Cain, Cain, Stuart A.; id_orcid   +3 more
core   +1 more source

Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants. [PDF]

Int J Mol Sci, 2023
Boeckel H, Karsten CM, Göpel W, Herting E, Rupp J, Härtel C, Hartz A.   +6 more
europepmc   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Weak response of porcine C5a receptor towards human C5a in miniature pig endothelial cells and PMNs

, 2007
BACKGROUND: The anaphylatoxin C5a is a potent inflammatory molecule generated during complement activation. Although some reports have implicated C5a in xenograft rejection, to date, the molecular compatibility between human C5a and porcine C5a receptor (
Kim, Hyori, Cho, Bumrae, Chung, Junho, Hwang, Seung Yong, Kim, Ki Tae, Yang, Jaeseok, Ahn, Curie, Bae, Yoe-Sik, Yi, Kye Sook, Kang, Hee Jung, Kang, Yoon-Ho, Kim, Min Soo, Ha, Insu, Lee, Sukmook, Bang, Ki Tae   +14 more
core   +1 more source

tRF3a-MetCAT Promotes EGFR-Targeted Therapeutic Resistance through the TRIM21–STAT1–C5a Axis in Lung Adenocarcinoma

Research
Despite the effectiveness of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in treating lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations, many patients eventually stop responding to therapy.
Yuchen Zhang, Pingjing Zhou, Yifan Guo, Hongyu Zhang, Jie Gu, Di Ge, Guangyin Zhao   +6 more
doaj   +1 more source

Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retinal pigment epithelial cells to oxidative stress. [PDF]

Biochim Biophys Acta Gen Subj, 2023
Ishii M, Rohrer B.
europepmc   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands

, 2016
A method of selectively modulating the activity of C5a receptor 2 (C5aR2). The method includes exposing the receptor to a compound that selectively modulates C5aR2 compared to C5a receptor 1 (C5aR1).
Monk, Peter N., Monikis, Dimitrios, Monikis, Dmitrios, Croker, Daniel E., Floudas, Christodoulos, Cooper, Matthew A., Monk, Peter, N., Woodruff, Trent   +7 more
core   +1 more source