Results 91 to 100 of about 16,368 (183)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, Volume 13, Issue 49, 3 September 2026.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Table_2_The repeat length of C9orf72 is associated with the survival of amyotrophic lateral sclerosis patients without C9orf72 pathological expansions.XLSX

, 2022
ObjectiveTo explore whether the repeat lengths of the chromosome 9 open reading frame 72 (C9orf72) gene and the ataxin-2 (ATXN2) gene in amyotrophic lateral sclerosis (ALS) patients without C9orf72 repeat expansions confer a risk of ALS or survival ...
Ji He (40669), Yan Ma (88810), Nan Zhang (46264), Lu Tang (655389), Xiaolu Liu (731063), Dongsheng Fan (817016), Lu Chen (75170)   +6 more
core   +1 more source

Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers

Molecular Neurodegeneration, 2020
Background A repeat expansion in the C9orf72-SMCR8 complex subunit (C9orf72) is the most common genetic cause of two debilitating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Jazmyne L. Jackson, NiCole A. Finch, Matthew C. Baker, Jennifer M. Kachergus, Mariely DeJesus-Hernandez, Kimberly Pereira, Elizabeth Christopher, Mercedes Prudencio, Michael G. Heckman, E. Aubrey Thompson, Dennis W. Dickson, Jaimin Shah, Björn Oskarsson, Leonard Petrucelli, Rosa Rademakers, Marka van Blitterswijk   +15 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

C9orf72 repeat expansions are a rare genetic cause of parkinsonism.: C9ORF72 repeat expansion in parkinsonism

, 2013
International audienceThe recently identified C9orf72 gene accounts for a large proportion of amyotrophic lateral sclerosis and frontotemporal lobar degenerations. As several forms of these disorders are associated with parkinsonism, we hypothesized that
Lesage, Suzanne, Rochefort, Daniel, Pasquier, Florence, Rouleau, Guy, A., Dion, Patrick,, Condroyer, Christel, Brice, Alexis, Broussolle, Emmanuel, Dürr, Alexandra, Gabelle, Audrey, Dion, Patrick, A., Le Ber, Isabelle, Thobois, Stéphane, Mondon, Karl, Rouleau, Guy,   +14 more
core   +1 more source

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. [PDF]

, 2016
Intronic hexanucleotide expansions in C9ORF72 are common in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non-ATG-initiated translation are ...
Daniel Hornburg, Sendtner, M., Drepper, C., Pamela J Shaw, Rajeeve Sivadasan, Meissner, F., Jablonka, S., Sterneckert, J., Shaw, P., Ince, P., Shaw, P.J., Nicolas Frank, Andreas Hermann, Frank, N., Jared Sterneckert, Hansel, A., Mann, M., Matthias Mann, Sivadasan, R., Anna Hansel, Hermann, A., Xenia Lojewski, Lojewski, X., Hornburg, D., Sibylle Jablonka, Felix Meissner, Carsten Drepper, Michael Sendtner, Paul G Ince, Ince, P.G.   +29 more
core   +1 more source

C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS‐STING Pathway

Immunity, Inflammation and Disease
Purpose C9orf72 deficiency contributes to severe inflammation in mice. Ulcerative colitis (UC) is a chronic inflammatory disorder with the shortage of clinical success. However, whether C9orf72 is involved in the progression of UC is not fully understood.
Yue Wang, Ting Xu, Wenjun Wang
doaj   +1 more source

Neural Stem Cell‐Derived Extracellular Vesicles Improve CNS Delivery and Therapeutic Efficacy of Antisense Oligonucleotide in Amyotrophic Lateral Sclerosis

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Passive ASO association with NSC‐EVs enhances neuronal uptake and CNS accumulation. NSC‐EV‐ASOs suppress pathogenic targets in ALS cellular models and, following intranasal administration, delay disease onset and improve motor function in SOD1‐G93A mice. These findings provide proof‐of‐concept evidence supporting NSC‐EVs as a platform for enhancing CNS
Yaochao Zheng, Taylor Jade Ellison, Robert Garrard, Jinghui Gao, Xinning Lai, Lin Lan, Jin Xie, Jie Jiang, Yao Yao   +8 more
wiley   +1 more source