Results 1 to 10 of about 51,631 (223)

ALS-linked FUS R521C disrupts arginine methylation of UBAP2L and stress granule dynamics

Journal of Analytical Science and Technology, 2023
Mutations in the fused-in-sarcoma (FUS) gene have been linked to familial amyotrophic lateral sclerosis (fALS). FUS aggregates in the cytosol and associates with stress granules (SGs) in pathological cases, whereas FUS is normally found in the nucleus ...
Mi-Hee Jun, Sang-Hee Lee, Yang Hoon Huh
doaj   +1 more source

Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS‐Associated Tumors

Genes, Chromosomes and Cancer, Volume 64, Issue 8, August 2025.
ABSTRACT We present a case of a 51‐year‐old male with a pseudoglandular cellular schwannoma arising from the brachial plexus, which contains the expected molecular aberrations for a schwannoma (chromosome 22q loss encompassing the NF2 and LZTR1 genes) as well as a FUS::KLF17 rearrangement.
Jerome Givi, Daisy Wu, Rania Bakkar, Michelle Afkhami, Diana Bell   +4 more
wiley   +1 more source

Regulation of physiological and pathological condensates by molecular chaperones

The FEBS Journal, Volume 292, Issue 13, Page 3271-3297, July 2025.
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree, Valentina Secco, Flonia Levy‐Adam, Amal Younis, Serena Carra, Reut Shalgi   +5 more
wiley   +1 more source

Genetic alterations of C9orf72, SOD1, TARDBP, FUS, and UBQLN2 genes in patients with Amyotrophic Lateral Sclerosis

Cogent Medicine, 2019
Amyotrophic lateral sclerosis is the most common motor neuron disease of the adulthood. Genetic analyses performed on cases with sporadic ALS (sALS) and familial ALS (fALS) have revealed mutations most commonly in the genes C9orf72, SOD1, TARDBP, FUS ...
Ciftci Vildan, Darbas Sule, Bilgen Turker, Uysal Hilmi, Karauzum Berker Sibel   +4 more
doaj   +1 more source

Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo. [PDF]

PLoS ONE, 2013
Amyotrophic lateral sclerosis (ALS) is a late onset and progressive motor neuron disease. Mutations in the gene coding for fused in sarcoma/translocated in liposarcoma (FUS) are responsible for some cases of both familial and sporadic forms of ALS.
Chiara Scaramuzzino, John Monaghan, Carmelo Milioto, Nicholas A Lanson, Astha Maltare, Tanya Aggarwal, Ian Casci, Frank O Fackelmayer, Maria Pennuto, Udai Bhan Pandey   +9 more
doaj   +1 more source

CYP24A1 Binding to FUS Maintains Tumor Properties by Regulating the miR‐200c/ZEB1/EMT Axis

Cancer Science, Volume 116, Issue 4, Page 910-922, April 2025.
The active vitamin D‐degrading enzyme (CYP24A1) is a potential oncogene in ovarian and lung cancer. Mechanically, 87–297 amino acid motif of CYP24A1 bound specifically to FUS protein, consequentially reducing FUS affinity for miR‐200c. A reduction in miR‐200c levels resulted in a significant activation of its target gene ZEB1, thereby facilitating the ...
Ping Wang, Jiming Xu, Weijing You, Jie Li, Jing Yu, Fei Jiang, Zengli Zhang, Wentao Hu, Bingyan Li   +8 more
wiley   +1 more source

A Chemotherapy Responsive Ewing Sarcoma Case Report With a Rare FUS::FLI1 Fusion

Case Reports in Pathology, Volume 2025, Issue 1, 2025.
Ewing sarcoma is a rare but aggressive type of cancer, primarily occurring in teenagers and young adults, characterized by having a small round cell morphology with positive diffuse membranous CD99 immunostaining of these small round blue cells. Although this cancer is often found in bones, it can also extend into the soft tissue in some cases.
Ismail M. Elbaz Younes, G. Thomas Budd, Yu-Wei Cheng, Suraiya Saleem   +3 more
wiley   +1 more source

Long non‐coding RNA MALAT1 triggers ferroptosis via interaction with FUS to enhance ACSF2 mRNA stabilization in septic acute kidney injury

The Kaohsiung Journal of Medical Sciences, Volume 40, Issue 11, Page 972-984, November 2024.
Abstract Septic acute kidney injury (AKI) is a fatal disease in the intensive care unit, with ferroptosis playing a crucial role in its pathogenesis. Long non‐coding RNA (LncRNA) metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) has been implicated in septic‐induced AKI inflammation and apoptosis.
Zhi‐Bing Duan, Ji‐Fu Zheng, Si‐Yue Huang, Li‐Li Hu   +3 more
wiley   +1 more source

Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations

Scientific Reports, 2021
Aberrantly expressed fused in sarcoma (FUS) is a hallmark of FUS-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Wildtype FUS localises to synapses and interacts with mitochondrial proteins while mutations have been shown ...
Shaakir Salam, Sara Tacconelli, Bradley N. Smith, Jacqueline C. Mitchell, Elizabeth Glennon, Nikolas Nikolaou, Corinne Houart, Caroline Vance   +7 more
doaj   +1 more source

Diagnostic and Therapeutic Implications of a FUS::TFCP2 Fusion and ALK Activation in a Metastatic Rhabdomyosarcoma

Genes, Chromosomes and Cancer, Volume 63, Issue 9, September 2024.
ABSTRACT The identification of gene fusions in rare sarcoma subtypes can have diagnostic, prognostic, and therapeutic impacts for advanced cancer patients. Here, we present a case of a 31‐year‐old male with a lytic lesion of the left mandible initially diagnosed as an osteosarcoma but found to have a TFCP2 fusion and ALK alteration, redefining the ...
Veronika Csizmok, Cameron J. Grisdale, Laura M. Williamson, Howard J. Lim, Lawrence Lee, Daniel J. Renouf, Steven J. M. Jones, Marco A. Marra, Janessa Laskin, Alannah Smrke   +9 more
wiley   +1 more source