Results 1 to 10 of about 26,469 (137)

Human FUS is toxic via association with RNA polymerase II in Drosophila [PDF]

Cell Death and Disease
The RNA-binding protein FUS is commonly mutated in familial cases of amyotrophic lateral sclerosis (ALS-FUS), where it forms cytoplasmic inclusions. In addition, non-mutated FUS is a constituent component of protein inclusions in approximately 5–10% of ...
Thomas G. Moens, Luca Biasetti, Wendy Scheveneels, Bradley N. Smith, Claire Troakes, Philip Van Damme, Caroline Vance, Ludo Van Den Bosch   +7 more
doaj   +2 more sources

Implementation of a High-Speed Multichannel Data Acquisition System for Magnetic Diagnostics and Plasma Centroid Position Control in ISTTOK

IEEE Access, 2023
In tokamak and other fusion devices, magnetic control is the main tool that allows to regulate the plasma current, position and shape; it is in charge of actuating the desired plasma current waveform, steering the plasma position to a given set point and
Domenica Corona, Adriano Mele, Nuno Cruz, Hugo Alves, Bernardo B. Carvalho, Humberto Figueiredo, Horacio Fernandes   +6 more
doaj   +1 more source

Heterogeneidad del tratamiento para cándida parapsilosis en endocarditis micótica de válvula nativa

Repertorio de Medicina y Cirugía, 2021
Las infecciones por cándida en el ámbito intrahospitalario han ido en ascenso en las últimas décadas en especial en las unidades de cuidado intensivo (UCI), dado el uso cada vez más frecuente de antibióticos de amplio espectro y de procedimientos ...
Gary Andrés Baquero , Jessica Cuervo , Evelin Moscoso , Diana Milena Bocanegra Rodríguez , Grégory Alfonso García Morán   +4 more
doaj   +1 more source

Genetics of familial amyotrophic lateral sclerosis

Бюллетень сибирской медицины, 2021
To analyze results of the studies covering modern scientific views on the genetics of familial amyotrophic lateral sclerosis (FALS).We searched for full-text publications containing the key words “amyotrophic lateral sclerosis”, “FALS”, and “genetics” in
A. V. Savinova, N. A. Shnayder, R. F. Nasyrova   +2 more
doaj   +1 more source

Development of the composition of a lubricant for injection under pressure with high sedimentation stability

Литьë и металлургия, 2020
The article describes the requirements for the lubricant used in injection molding of non-ferrous alloys. A methodology for conducting research to determine the sedimentation stability of a prepared lubricant is presented, as well as the results of a ...
A. A. Pivovarchyk, A. M. Mikhaltsov, Ya. I. Tsishkova   +2 more
doaj   +1 more source

Clearance of HR-HPV within one year after focused ultrasound or loop electrosurgical excision procedure in patients with HSIL under 30

International Journal of Hyperthermia, 2022
Objective To compare the clearance rate of high-risk human papillomavirus (HR-HPV) in patients with a high-grade squamous intraepithelial lesion (HSIL) 12 months after focused ultrasound (FUS) or loop electrosurgical excision procedure (LEEP), and ...
Yi Qin, Qing Li, Xunyu Ke, Yan Zhang, Xiaoling Shen, Wenping Wang, Qiuling Shi, Chengzhi Li   +7 more
doaj   +1 more source

Small junction, big problems: Neuromuscular junction pathology in mouse models of amyotrophic lateral sclerosis (ALS)

Journal of Anatomy, Volume 241, Issue 5, Page 1089-1107, November 2022., 2022
Summary of neuromuscular junction (NMJ) changes across ALS mouse models. ALS mouse models show different levels of NMJ pathology depending on gene targets: SOD1, TDP‐43 and FUS models all show initial NMJ dysfunction prior to motor neuron death (arrows), supporting a ‘dying‐back’ theory, while C9orf72 NMJ pathology is less clear. Terminal Schwann cells
Abrar Alhindi, Ines Boehm, Helena Chaytow   +2 more
wiley   +1 more source

A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice

CNS Neuroscience &Therapeutics, Volume 27, Issue 7, Page 765-775, July 2021., 2021
DF402, a fluorine derivative of Dimebon/Latrepirdine, delays the onset and slows the progression of pathology in the transgenic model of ALS‐FUS. An original CatWalk analysis protocol allowing detection of gait changes in FUS transgenic mice long before manifestation of clinical signs reveals effects of DF402 on their gait at early pre‐symptomatic ...
Kirill Chaprov, Alexander Rezvykh, Sergei Funikov, Tamara A. Ivanova, Ekaterina A. Lysikova, Alexei V. Deykin, Michail S. Kukharsky, Alexey Yu. Aksinenko, Sergey O. Bachurin, Natalia Ninkina, Vladimir L. Buchman   +10 more
wiley   +1 more source

Clinical efficacy and mechanism for focused ultrasound (FUS) in the management of cervical intraepithelial neoplasia 1 (CIN1)

International Journal of Hyperthermia, 2020
Objective This study was aimed at investigating the clinical efficacy and studying the possible mechanism of FUS applications to treat cervical intraepithelial neoplasia 1 (CIN1).
Zhenhua Fu, Yijin Fan, Can Wu, Ping Yan, Yibi Ye, Huan Yang, Chengzhi Li   +6 more
doaj   +1 more source

Sobel edge detection for quantifying the effectiveness of focused ultrasound thalamotomy for tremor relief

Current Directions in Biomedical Engineering, 2023
Focused ultrasound on the thalamus is employed to relieve tremor in movement disorders. The treatment efficacy is currently assessed by subjective observation of patient tremor during hand movements.
Aharonson Vered, Postema Michiel, Gebbie Robyn, Van Der Merwe Jesse, Schlesinger Ilana   +4 more
doaj   +1 more source