Results 31 to 40 of about 48,475 (224)
Molecular Oncology, Volume 14, Issue 11, Page 2936-2959, November 2020., 2020 Interaction of BTB and CNC homolog 2 (BACH2) with fused in sarcoma (FUS) promoted glioma progression via transcriptional inhibition of TSLNC8. Overexpression of TSLNC8 restrained glioma progression by suppressing miR‐10b‐5p. Binding of TSLNC8 to miR‐10b‐5p attenuated the suppression of WWC family member 3 (WWC3) by miR‐10b‐5p and activated the Hippo ...
Yang Yang +11 more
wiley +1 more source
Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants [PDF]
, 2016 Fused in sarcoma (FUS) is a ubiquitously expressed RNA-binding protein proposed to function in various RNA metabolic pathways, including transcription regulation, pre-mRNA splicing, RNA transport and microRNA processing.
Martino Colombo +29 more
core +1 more source
Brain Stimulation, 2023 Background: Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders.
Dong Liu +6 more
doaj +1 more source
Genetic testing of FUS, HTRA2, and TENM4 genes in Chinese patients with essential tremor
CNS Neuroscience &Therapeutics, Volume 26, Issue 8, Page 837-841, August 2020., 2020 Abstract Introduction Essential tremor (ET) is one of the most prevalent movement disorders. The genetic etiology of ET has not been well defined although a significant proportion (≥50%) are familial cases. Linkage analysis and genome‐wide association studies (GWASs) have identified several risk variants.
Ya‐Ping Yan +10 more
wiley +1 more source
Brain Stimulation, 2020 Background: Transcranial focused ultrasound (tFUS) is a noninvasive brain stimulation method that may modulate deep brain structures. This study investigates whether sonication of the right anterior thalamus would modulate thermal pain thresholds in ...
Bashar W. Badran +12 more
doaj +1 more source
Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS
Frontiers in Molecular Neuroscience, 2021 Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood.
Clara Tejido +4 more
doaj +1 more source
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. [PDF]
PLoS Biology, 2011 TDP-43 and FUS are RNA-binding proteins that form cytoplasmic inclusions in some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, mutations in TDP-43 and FUS are linked to ALS and FTLD.
Zhihui Sun +6 more
doaj +1 more source
US-tracked steered FUS in a respiratory ex vivo ovine liver phantom
Current Directions in Biomedical Engineering, 2015 Organ motion is a major problem for Focused Ultrasound Surgery (FUS) of liver tumors. We present a liver phantom mimicking human respiratory motion (20 mm range, 3 − 7 s/cycle) and the evaluation of an ultrasound-tracked steered FUS system on that ...
Strehlow Jan +9 more
doaj +1 more source
FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees [PDF]
, 2021 Mutations in FUS and TBK1 often cause aggressive early-onset amyotrophic lateral sclerosis (ALS) or a late-onset ALS and/or frontotemporal dementia (FTD) phenotype, respectively.
Ludolph, Albert C., +21 more
core +3 more sources