Results 51 to 60 of about 51,631 (223)

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 5, May 2026.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes

, 2023
International audienceCytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Jean-Christophe Cassel, Rafael Alcala-Vida, Dieterlé, Stéphane, Isabel Paiva, Seguin, Jonathan, Jonathan Seguin, Paiva, Isabel, Damien Plassard, Cosquer, Brigitte, Charles Decraene, Megat, Salim, Le Gras, Stéphanie, Decraene, Charles, Alcalá-Vida, Rafael, Dupuis, Luc, Plassard, Damien, Anne-Laurence Boutillier, Brigitte Cosquer, Stéphanie Le Gras, Boutillier, Anne-Laurence, Salim Megat, Tzeplaeff, Laura, Karine Merienne, Cassel, Jean-Christophe, Stéphane Dieterlé, Gina Picchiarelli, Laura Tzeplaeff, Luc Dupuis, Merienne, Karine, Picchiarelli, Gina   +29 more
core   +1 more source

Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

Aggregate, Volume 6, Issue 12, December 2025.
We demonstrate a domain‐specific preferential distribution organization of FUS condensate and propose a sequence–structure–function paradigm for biomolecular condensates. ABSTRACT Biomolecular condensates play crucial roles in cellular physiology and are implicated in neurodegenerative diseases and cancer.
Si‐Cheng Tong, Yang Jiang, Yi‐Nan Guo, Yong Wang, Li Zhao, Zhong‐Yuan Lu   +5 more
wiley   +1 more source

Multiple‐point magnetic resonance acoustic radiation force imaging

Magnetic Resonance in Medicine, Volume 81, Issue 2, Page 1104-1117, February 2019., 2019
Abstract Purpose To implement and evaluate an efficient multiple‐point MR acoustic radiation force imaging pulse sequence that can volumetrically measure tissue displacement and evaluate tissue stiffness using focused ultrasound (FUS) radiation force. Methods Bipolar motion‐encoding gradients were added to a gradient‐recalled echo segmented EPI pulse ...
Henrik Odéen, Joshua de Bever, Lorne W. Hofstetter, Dennis L. Parker   +3 more
wiley   +1 more source

Mesenchymal stem cell–derived extracellular vesicle treatment of induced pluripotent stem cell–derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds

Neural Regeneration Research
Motor neurons derived from induced human pluripotent stem cells offer a powerful model to study motor neuron diseases, such as amyotrophic lateral sclerosis. While widely used, our knowledge of the proteomic changes in these models is rather rudimentary.
Suzy Varderidou-Minasian, Channa E. Jakobs, Svetlana Pasteuning-Vuhman, Lars Gal, Annabel Timmers, Maarten Altelaar, Magdalena J. Lorenowicz, R. Jeroen Pasterkamp   +7 more
doaj   +1 more source

Validity and Reliability of the Fundamental Motor Skills in Sports (FUS) Test for Iranian Children and Adolescents [PDF]

International Journal of School Health
Background: Confident and proficient participation in physical activities throughout life relies on mastering Fundamental Motor Skills. Given the need for more effective solutions in assessing fundamental basic skills in both children and adolescents ...
Mohammad Hossein Zamani, Ayoub Hashemi, Elahe Siavashi, Razieh Khanmohamadi, Hamideh Saeidi   +4 more
doaj   +1 more source

Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates

Scientific Reports, 2022
Genetic mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). Although mitochondrial dysfunction and stress granule have been crucially implicated in FUS proteinopathy, the molecular basis remains unclear.
Ryota Hikiami, Toshifumi Morimura, Takashi Ayaki, Tomoyuki Tsukiyama, Naoko Morimura, Makiko Kusui, Hideki Wada, Sumio Minamiyama, Akemi Shodai, Megumi Asada-Utsugi, Shin-ichi Muramatsu, Takatoshi Ueki, Ryosuke Takahashi, Makoto Urushitani   +13 more
doaj   +1 more source

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS

Aging Cell, Volume 24, Issue 11, November 2025.
We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann, Christina Haß, Muriel Knobloch, Israel Barrantes, Laura Fumagalli, Jessie Premereur, Franz Markert, Maite Peters, Georgia Koromila, Alexander Hartmann, Kathrin Jäger, Jette Abel, Renzo Mancuso, Alexander Storch, Michael Walter, Georg Fuellen, Andreas Hermann   +16 more
wiley   +1 more source

The ALS/FTLD‐related RNA‐binding proteins TDP‐43 and FUS have common downstream RNA targets in cortical neurons

FEBS Open Bio, Volume 4, Issue 1, Page 1-10, January 01, 2014., 2014
TDP‐43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and loss of function of either protein contributes to these neurodegenerative conditions. To elucidate the TDP‐43‐ and FUS‐regulated pathophysiological RNA metabolism cascades, we assessed the differential gene expression and alternative ...
Daiyu Honda, Shinsuke Ishigaki, Yohei Iguchi, Yusuke Fujioka, Tsuyoshi Udagawa, Akio Masuda, Kinji Ohno, Masahisa Katsuno, Gen Sobue   +8 more
wiley   +1 more source