Results 61 to 70 of about 48,475 (224)
Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS‐Associated Tumors
Genes, Chromosomes and Cancer, Volume 64, Issue 8, August 2025.ABSTRACT We present a case of a 51‐year‐old male with a pseudoglandular cellular schwannoma arising from the brachial plexus, which contains the expected molecular aberrations for a schwannoma (chromosome 22q loss encompassing the NF2 and LZTR1 genes) as well as a FUS::KLF17 rearrangement.
Jerome Givi +4 more
wiley +1 more source
The role of FUS in splicing regulation [PDF]
, 2014 Fused in sarcoma (FUS), also called translocated in liposarcoma (TLS), is a ubiquitously expressed DNA/RNA binding protein belonging to the TET family and predominantly localized in the nucleus.
Ruepp, Marc-David
core
FUS CLIP-seq identified increased FUS binding in introns flanking cassette exons. [PDF]
, 2013 A) FUS CLIP assay conditions. B) Western blot analysis of FUS protein immunoprecipitated from FUS CLIP. C) Autoradiography of radiolabeled FUS-RNA complexes from FUS CLIP. Red boxes highlight FUS protein complex regions selected for further analysis.
Geoffrey G. Hicks (14105) +4 more
core +1 more source
ALS-linked FUS R521C disrupts arginine methylation of UBAP2L and stress granule dynamics
Journal of Analytical Science and Technology, 2023 Mutations in the fused-in-sarcoma (FUS) gene have been linked to familial amyotrophic lateral sclerosis (fALS). FUS aggregates in the cytosol and associates with stress granules (SGs) in pathological cases, whereas FUS is normally found in the nucleus ...
Mi-Hee Jun, Sang-Hee Lee, Yang Hoon Huh
doaj +1 more source
Regulation of physiological and pathological condensates by molecular chaperones
The FEBS Journal, Volume 292, Issue 13, Page 3271-3297, July 2025.Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree +5 more
wiley +1 more source
Proteomic characterization of the FUS/TLS interactome [PDF]
, 2014 FUS/TLS (fused in sarcoma/translocated in liposarcoma) is a ubiquitously expressed RNA-binding protein, that has been discovered as fused to transcription factors in several human sarcomas and found in protein aggregates in neurons of patients with an ...
Ruepp, Marc-David
core
CYP24A1 Binding to FUS Maintains Tumor Properties by Regulating the miR‐200c/ZEB1/EMT Axis
Cancer Science, Volume 116, Issue 4, Page 910-922, April 2025.The active vitamin D‐degrading enzyme (CYP24A1) is a potential oncogene in ovarian and lung cancer. Mechanically, 87–297 amino acid motif of CYP24A1 bound specifically to FUS protein, consequentially reducing FUS affinity for miR‐200c. A reduction in miR‐200c levels resulted in a significant activation of its target gene ZEB1, thereby facilitating the ...
Ping Wang +8 more
wiley +1 more source
MRI results after FUS sonication. [PDF]
, 2014 A: In-house submicron bubbles with 10-MHz FUS sonication. B: SonoVue with 10-MHz FUS sonication. C: In-house submicron bubbles with 1-MHz FUS sonication. D: SonoVue with 1-MHz FUS sonication.
Ya-Hsuan Lee (558660) +8 more
core +1 more source
Cogent Medicine, 2019 Amyotrophic lateral sclerosis is the most common motor neuron disease of the adulthood. Genetic analyses performed on cases with sporadic ALS (sALS) and familial ALS (fALS) have revealed mutations most commonly in the genes C9orf72, SOD1, TARDBP, FUS ...
Ciftci Vildan +4 more
doaj +1 more source
A Chemotherapy Responsive Ewing Sarcoma Case Report With a Rare FUS::FLI1 Fusion
Case Reports in Pathology, Volume 2025, Issue 1, 2025.Ewing sarcoma is a rare but aggressive type of cancer, primarily occurring in teenagers and young adults, characterized by having a small round cell morphology with positive diffuse membranous CD99 immunostaining of these small round blue cells. Although this cancer is often found in bones, it can also extend into the soft tissue in some cases.
Ismail M. Elbaz Younes +3 more
wiley +1 more source