Results 61 to 70 of about 51,631 (223)

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis

Cell Reports, 2019
Summary: Mutations in the FUS gene cause familial amyotrophic lateral sclerosis (ALS-FUS). In ALS-FUS, FUS-positive inclusions are detected in the cytoplasm of neurons and glia, a condition known as FUS proteinopathy.
Tatyana A. Shelkovnikova, Haiyan An, Lucy Skelt, John S. Tregoning, Ian R. Humphreys, Vladimir L. Buchman   +5 more
doaj   +1 more source

Solid state NMR spectra of FUS-LC-C, FUS-LC-N, and FUS-LC fibrils

, 2020
2D NCACX and C-C solid state NMR spectra of fibrils formed by the 214-residue low-complexity domain of the FUS protein (FUS-LC), by residues 111-214 (FUS-LC-C), and by residues 2-108 (FUS-LC-N). All samples were uniformly 15N and 13C labeled.
Tycko, R (via Mendeley Data)
core   +1 more source

TLS/FUS [PDF]

Cell Cycle, 2012
Comment on: Tan AY, et al. Proc Natl Acad Sci USA 2012; 109:6030-5.
Tan, Adelene Y., Manley, James L.
openaire   +2 more sources

Exosomal HSPB1, interacting with FUS protein, suppresses hypoxia‐induced ferroptosis in pancreatic cancer by stabilizing Nrf2 mRNA and repressing P450

Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.
Abstract Ferroptosis is a new type of programmed cell death, which has been involved in the progression of tumours. However, the regulatory network of ferroptosis in pancreatic cancer is still largely unknown. Here, using datasets from GEO and TCGA, we screened HSPB1, related to the P450 monooxygenase signalling, a fuel of ferroptosis, to be a ...
Lun Zhang, Liuxu Yang, Keyuan Du
wiley   +1 more source

Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India

Indian Journal of Pathology and Microbiology
Background and Aim: Ewing family of tumors (EFT) encompass a group of small blue round cell tumors, including Ewing sarcoma (ES) and EWSR1-negative undifferentiated small round cell sarcoma.
Mukund N. Sable, JN Aparnna, Suvendu Purkait   +2 more
doaj   +1 more source

Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging

Neurobiology of Disease, 2015
Autosomal-dominant mutations within the gene FUS (fused in sarcoma) are responsible for 5% of familial cases of amyotrophic lateral sclerosis (ALS). The FUS protein is physiologically mainly located in the nucleus, while cytoplasmic FUS aggregates are ...
Julia Japtok, Xenia Lojewski, Marcel Naumann, Moritz Klingenstein, Peter Reinhardt, Jared Sterneckert, Stefan Putz, Maria Demestre, Tobias M. Boeckers, Albert C. Ludolph, Stefan Liebau, Alexander Storch, Andreas Hermann   +12 more
doaj   +1 more source

Spindle cell rhabdomyosarcomas: With TFCP2 rearrangements, and novel EWSR1::ZBTB41 and PLOD2::RBM6 gene fusions. A study of five cases and review of the literature

Histopathology, Volume 84, Issue 5, Page 776-793, April 2024.
Aims Spindle‐cell/sclerosing rhabdomyosarcomas (SS‐RMS) are clinically and genetically heterogeneous. They include three well‐defined molecular subtypes, of which those with EWSR1/FUS::TFCP2 rearrangements were described only recently. This study aimed to evaluate five new cases of SS‐RMS and to perform a clinicopathological and statistical analysis of
Martina Bradová, Elaheh Mosaieby, Michael Michal, Tomáš Vaněček, Stanislav Kormunda Ing, Petr Grossmann, Olena Koshyk, Zdeněk Kinkor, Šimon Laciok, Antónia Nemcová, Ľubomír Straka, Mihaela Farkas, Michal Michal, Marián Švajdler   +13 more
wiley   +1 more source

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

Molecular Neurodegeneration, 2012
Background Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD).
Verbeeck Christophe, Deng Qiudong, DeJesus-Hernandez Mariely, Taylor Georgia, Ceballos-Diaz Carolina, Kocerha Jannet, Golde Todd, Das Pritam, Rademakers Rosa, Dickson Dennis W, Kukar Thomas   +10 more
doaj   +1 more source

Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis

Brain Pathology, Volume 34, Issue 2, March 2024.
Abstract FUS mutations are one of the major mutations in familial amyotrophic lateral sclerosis (ALS). The pathological hallmark is FUS‐positive neuronal cytoplasmic inclusions (FUS‐NCI), known as FUS proteinopathy. Human myxovirus resistance protein 1 (MxA) is an IFN‐induced dynamin‐like GTPase that acts as antiviral factor. In this study, we examined
Hiroyuki Honda, Kaoru Yagita, Hajime Arahata, Hideomi Hamasaki, Hideko Noguchi, Sachiko Koyama, Naokazu Sasagasako   +6 more
wiley   +1 more source

Italian Theatre Today: Not a System, and so Many Transformations

Critical Stages, 2019
Far from being a system, the Italian scene is an agglomeration where historical events, linguistic varieties, places of creation, small and large legislative provisions and artists’ personality shake the theatres and their audiences in an animated chaos.
Roberto Canziani
doaj