Results 81 to 90 of about 51,631 (223)

Proteomic characterization of the FUS/TLS interactome

, 2014
FUS/TLS (fused in sarcoma/translocated in liposarcoma) is a ubiquitously expressed RNA-binding protein, that has been discovered as fused to transcription factors in several human sarcomas and found in protein aggregates in neurons of patients with an ...
Ruepp, Marc-David
core  

FUS and Prostate

, 2020
In this study, we evaluated FUS expression in non-neoplastic tissue and prostatic adenocarcinoma, the association between FUS expression and clinical/laboratory progression, and the ability of FUS expression to predict Gleason scores >6 in Gleason ...
HIRTH, C (via Mendeley Data)
core   +1 more source

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

Acta Neuropathologica Communications, 2019
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in the nucleus are less understood.
Haiyan An, Lucy Skelt, Antonietta Notaro, J. Robin Highley, Archa H. Fox, Vincenzo La Bella, Vladimir L. Buchman, Tatyana A. Shelkovnikova   +7 more
doaj   +1 more source

The FUS protein is required for cell proliferation

, 2013
FUS/TLS (fused in sarcoma/translocated in liposarcoma) protein, a ubiquitously expressed and highly conserved RNA binding protein, has been linked to a variety of cellular processes from mRNA processing to DNA repair. However, the precise function of FUS
Ruepp, Marc-David
core  

Activity-dependent FUS dysregulation disrupts synaptic homeostasis [PDF]

, 2014
The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative disorders that share similar clinical and pathological features. Both missense
Herz, Joachim, Huber, Kimberly M, Tang, Amy A, West, James, Stubblefield, Jeremy J., Huang, Eric J, Sephton, Chantelle F., Huang, Eric J., Liu, Yun, Kulkarni, Ashwinikumar, Stubblefield, Jeremy J, Green, Carla B, Green, Carla B., Sephton, Chantelle F, Huber, Kimberly M., Brooks, Mieu, Zhang, Michael Q, Yu, Gang, Zhang, Michael Q., Tang, Amy A.   +19 more
core   +1 more source

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

eLife, 2019
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation.
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland   +27 more
doaj   +1 more source

FUS CLIP-seq identified increased FUS binding in introns flanking cassette exons.

, 2013
A) FUS CLIP assay conditions. B) Western blot analysis of FUS protein immunoprecipitated from FUS CLIP. C) Autoradiography of radiolabeled FUS-RNA complexes from FUS CLIP. Red boxes highlight FUS protein complex regions selected for further analysis.
Geoffrey G. Hicks (14105), Arzu Öztürk (478466), Yueqin Zhou (478465), Songyan Liu (14109), Guodong Liu (278986)   +4 more
core   +1 more source

MRI results after FUS sonication.

, 2014
A: In-house submicron bubbles with 10-MHz FUS sonication. B: SonoVue with 10-MHz FUS sonication. C: In-house submicron bubbles with 1-MHz FUS sonication. D: SonoVue with 1-MHz FUS sonication.
Ya-Hsuan Lee (558660), Yan-Jung Ma (558662), Chih-Kuang Yeh (558663), Kuo-Chen Wei (383166), Ching-Hsiang Fan (558658), Hao-Li Liu (383171), Chien-Yu Ting (558659), Chih-Ying Huang (558661), Tzu-Chen Yen (210149)   +8 more
core   +1 more source

Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

Molecular Neurodegeneration
RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS) and about 10%
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz   +12 more
doaj   +1 more source

FUS affects splicing of minor introns: Implications for ALS

, 2016
Fused in sarcoma (FUS) is a ubiquitously expressed protein of the hnRNP family and has several reported functions in diverse RNA metabolic pathways. Among them regulation of transcription, pre-mRNA splicing, mRNA transport and miRNA processing.
Reber, Stefan
core