Results 91 to 100 of about 51,631 (223)
FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.
PLoS Genetics, 2011 Mutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and sporadic (SALS) patients.
Edor Kabashi +6 more
doaj +1 more source
The multifunctional FUS protein: Characterization of the biological effects of its depletion
, 2013 FUS/TLS (fused in sarcoma/translocated in liposarcoma) protein, a ubiquitously expressed RNA-binding protein, has been linked to a variety of cellular processes, such as RNA metabolism, microRNA biogenesis and DNA repair. However, the precise role of FUS
Ruepp, Marc-David
core
Frontiers in Cell and Developmental Biology, 2019 BackgroundLncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs in temozolomide (TMZ) resistance in glioblastoma (GBM) remain to be elucidated.MethodsTo elucidate the mechanism ...
Yuanliang Yan +19 more
doaj +1 more source
An ALS-associated mutation in the FUS 3′2-UTR disrupts a microRNA-FUS regulatory circuitry
, 2014 While the physiologic functions of the RNA-binding protein FUS still await thorough characterization, the pathonegetic role of FUS mutations in amyotrophic lateral sclerosis (ALS) is clearly established.
Sabatelli M. +4 more
core +2 more sources
PLoS ONE, 2014 FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons.
Jamie Rae Acosta +11 more
doaj +1 more source
Unravelling the multiple roles of FUS in RNA processing and on ALS pathogenesis
, 2013 Two genes with related functions in RNA biogenesis were recently reported in patients with familial ALS: the FUS/TLS gene at the ALS6 locus and the TARDBP/TDP-43 gene at the ALS10 locus [1, 2].
Ruepp, Marc-David
core
Exogenous expression of FUS can rescue the depletion of endogenous FUS to repress exon 7.
, 2013 A) Schematic of the rescue assay. FUS protein was first knocked down by siRNA targeting 3′ UTR of FUS for 48 h and then increased by the expression of EGFP-FUS plasmid for 24 h in HEK293 cells. B) Western blot analysis of FUS in the rescue assay.
Geoffrey G. Hicks (14105) +4 more
core +1 more source
Proceedings of the National Academy of SciencesAtmospheric scientist Qiang Fu uses satellite observations, numerical simulations, and theoretical analysis to investigate how changes across different layers of the atmosphere—and their circulation—are linked to climate change. Early in his career, Fu advanced the understanding and modeling of radiative transfer in Earth’s atmosphere.
openaire +2 more sources
Characterization of the role of the RNA-binding protein FUS in the DNA damage response
, 2014 FUS/TLS (fused in sarcoma/translocated in liposarcoma), a ubiquitously expressed RNA-binding protein, has been linked to a variety of cellular processes, including RNA metabolism, microRNA biogenesis and DNA repair. However, the precise cellular function
Ruepp, Marc-David
core
Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations [PDF]
, 2018 Accumulation of the DNA/RNA binding protein fused in sarcoma (FUS) as inclusions in neurons and glia is the pathological hallmark of amyotrophic lateral sclerosis patients with mutations in FUS (ALS-FUS) as well as in several subtypes of frontotemporal ...
Ishihara, Kenji +10 more
core