Results 101 to 110 of about 48,475 (224)

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

eLife, 2019
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation.
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland   +27 more
doaj   +1 more source

Metodfrågor i ungdomskulturforskningen [PDF]

, 1990
This is the first of a series of reports from the research program Youth culture in Sweden, FUS. It contains five texts on methodological issues, three written by the members of the FUS central group that edits this series, and two by other researchers ...

core   +2 more sources

Novel Function of lncRNA ADAMTS9-AS2 in Promoting Temozolomide Resistance in Glioblastoma via Upregulating the FUS/MDM2 Ubiquitination Axis

Frontiers in Cell and Developmental Biology, 2019
BackgroundLncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs in temozolomide (TMZ) resistance in glioblastoma (GBM) remain to be elucidated.MethodsTo elucidate the mechanism ...
Yuanliang Yan, Yuanliang Yan, Zhijie Xu, Xi Chen, Xi Chen, Xiang Wang, Xiang Wang, Shuangshuang Zeng, Shuangshuang Zeng, Zijin Zhao, Long Qian, Long Qian, Zhi Li, Jie Wei, Jie Wei, Lei Huo, Xuejun Li, Zhicheng Gong, Zhicheng Gong, Lunquan Sun   +19 more
doaj   +1 more source

Activity-dependent FUS dysregulation disrupts synaptic homeostasis [PDF]

, 2014
The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative disorders that share similar clinical and pathological features. Both missense
Herz, Joachim, Huber, Kimberly M, Tang, Amy A, West, James, Stubblefield, Jeremy J., Huang, Eric J, Sephton, Chantelle F., Huang, Eric J., Liu, Yun, Kulkarni, Ashwinikumar, Stubblefield, Jeremy J, Green, Carla B, Green, Carla B., Sephton, Chantelle F, Huber, Kimberly M., Brooks, Mieu, Zhang, Michael Q, Yu, Gang, Zhang, Michael Q., Tang, Amy A.   +19 more
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Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

Molecular Neurodegeneration
RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS) and about 10%
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz   +12 more
doaj   +1 more source

FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.

PLoS Genetics, 2011
Mutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and sporadic (SALS) patients.
Edor Kabashi, Valérie Bercier, Alexandra Lissouba, Meijiang Liao, Edna Brustein, Guy A Rouleau, Pierre Drapeau   +6 more
doaj   +1 more source

Software Implementation for GTL FUs [PDF]

, 2012
The GLT configuration includes: - GTL Processing FUs - GTL Utility FUs - GTL Auxiliary ...
Preda, Marius, Tulvan, Christian Liviu
core   +2 more sources

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations [PDF]

, 2018
Accumulation of the DNA/RNA binding protein fused in sarcoma (FUS) as inclusions in neurons and glia is the pathological hallmark of amyotrophic lateral sclerosis patients with mutations in FUS (ALS-FUS) as well as in several subtypes of frontotemporal ...
Ishihara, Kenji, Ang, Lee-Cyn, Neumann, Manuela, Valori, Chiara, Kretzschmar, Hans, Munoz, David, Yokota, Osamu, Mackenzie, Ian, Kusaka, Hirofumi, Ansorge, Olaf, Bilbao, Juan   +10 more
core  

Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice

The Journal of Clinical Investigation
Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus,
Manuel Chiusa, Youngmin A. Lee, Ming-Zhi Zhang, Raymond C. Harris, Taylor Sherrill, Volkhard Lindner, Craig R. Brooks, Gang Yu, Agnes B. Fogo, Charles R. Flynn, Jozef Zienkiewicz, Jacek Hawiger, Roy Zent, Ambra Pozzi   +13 more
doaj   +1 more source

Fu You: FU Institution Intervention [PDF]

Scope: Contemporary Research Topics (Art & Design), 2019
openaire   +1 more source