Results 71 to 80 of about 51,631 (223)

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules [PDF]

, 2013
Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing.
Miller, CC, Catherine Manser, Claire Troakes, Troakes, C, Claudia Kathe, Scotter, Emma, Boris Rogelj, Urwin, Hazel, Mitchell, JC, Scotter, EL, Kathe, Claudia, Nishimura, AL, Dragunow, M, Rogelj, Boris, Rogelj, B, Emma L. Scotter, Manser, Catherine, Urwin, H, Hortobágyi, Tibor, Shaw, Christopher E., Mitchell, Jacqueline C., Tibor Hortobágyi, Vance, Caroline; id_orcid, Agnes L. Nishimura, Nishimura, Agnes L., Caroline Vance, Jacqueline C. Mitchell, Dragunow, Mike, Dragunow, Michael, Shaw, CE, Vance, C, Scotter, Emma L., Troakes, Claire; id_orcid, Kathe, C, Hortobágyi, T, Manser, C, Mike Dragunow, Christopher E. Shaw, Hazel Urwin, Christopher C. Miller, Miller, Christopher C.; id_orcid   +40 more
core   +1 more source

Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice [PDF]

, 2020
FUS is a primarily nuclear RNA-binding protein with important roles in RNA processing and transport. FUS mutations disrupting its nuclear localization characterize a subset of amyotrophic lateral sclerosis (ALS-FUS) patients, through an unidentified ...
Pérez-Berlanga, Manuela, Sahadevan, Sonu, Hembach, Katharina M, Robinson, Mark D, De Rossi, Pierre, Weber, Julien, Tantardini, Elena, Dupuis, Luc, Hruska-Plochan, Marian, Polymenidou, Magdalini, Schwarz, Petra   +10 more
core   +1 more source

FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

PLoS Genetics, 2011
Fused in Sarcoma (FUS) proteinopathy is a feature of frontotemporal lobar dementia (FTLD), and mutation of the fus gene segregates with FTLD and amyotrophic lateral sclerosis (ALS).
Cao Huang, Hongxia Zhou, Jianbin Tong, Han Chen, Yong-Jian Liu, Dian Wang, Xiaotao Wei, Xu-Gang Xia   +7 more
doaj   +1 more source

The FUS(s) about splicing

, 2014
Fused in sarcoma (FUS), also called translocated in liposarcoma (TLS), is a ubiquitously expressed DNA/RNA binding protein belonging to the TET family and predominantly localized in the nucleus.
Ruepp, Marc-David
core  

Transportin 1 co-localisation with FUS inclusions is not characteristic for ALS-FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from FTLD-FUS

, 2012
Aims:  Transportin 1 (TNPO 1) is an abundant component of the Fused in Sarcoma (FUS)-immunopositive inclusions seen in a subgroup of frontotemporal lobar degeneration (FTLD-FUS).
Al-Sarraj, Safa, Troakes, C; id_orcid, Vance, C; id_orcid, Rogelj, B, Hortobágyi, T, Shaw, C E   +5 more
core   +1 more source

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila

Neurobiology of Disease, 2015
Inclusions containing Fused in Sarcoma (FUS) are found in familial and sporadic cases of the incurable progressive motor neuron disease amyotrophic lateral sclerosis and in a common form of dementia, frontotemporal dementia.
Sandra Jäckel, Anna K. Summerer, Catherine M. Thömmes, Xia Pan, Aaron Voigt, Jörg B. Schulz, Tobias M. Rasse, Dorothee Dormann, Christian Haass, Philipp J. Kahle   +9 more
doaj   +1 more source

Number of differentially expressed genes by mutant FUS, FUS overexpression, and FUS knock-down.

, 2013
Number of differentially expressed genes by mutant FUS, FUS overexpression, and FUS knock-down.
John E. Landers (172264), Marka van Blitterswijk (119410), Ashley Lyn Leclerc (400572), Eric T. Wang (256097), Pamela J. Keagle (400570), Jan H. Veldink (119438), David E. Housman (254310), Brad A. Friedman (400569), Leonard H. van den Berg (119440), Patrick Lowe (400571)   +9 more
core   +1 more source

HSP60 interacts with FUS, mediating FUS mitochondrial localization.

, 2016
(A) FUS-HSP60 interaction was detected by co-immunoprecipitation assay. Western blotting (WB) was performed using corresponding specific antibodies following immunoprecipitation of cell lysates with anti-GFP.(B)FUS-HSP60 interaction was detected by co ...
Marsel Mesulam (2207017), Jianghong Liu (392919), Jianwen Deng (2207002), Qi Xu (134661), Yang Li (7082), Sidan Du (2207014), Eileen H. Bigio (85389), Li Zhu (67404), Haipeng Cheng (2207011), Mengxue Yang (2207005), Jane Y. Wu (36803), Yanbo Chen (2207008), Xiaoping Chen (42085), Kazuo Fushimi (36798), Shufeng Sun (2196031)   +14 more
core   +1 more source

FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees

, 2021
Mutations in FUS and TBK1 often cause aggressive early-onset amyotrophic lateral sclerosis (ALS) or a late-onset ALS and/or frontotemporal dementia (FTD) phenotype, respectively.
Ludolph, Albert C.,, Andersen, Peter M.,, Ludolph, Albert C., Andersen, Peter M., Knehr, Antje,, Yilmaz, Rüstem, Brenner, David,, Müller, Kathrin,, Weishaupt, Jochen H., Ludolph, Albert C, Freischmidt, Axel,, Yılmaz, Rüstem, Brenner, David, Yilmaz, Rüstem,, Müller, Kathrin, Lattante, Serena, Knehr, Antje, Andersen, Peter M, Weishaupt, Jochen H, Freischmidt, Axel, Weishaupt, Jochen H.,, Lattante, Serena,   +21 more
core   +1 more source

The role of FUS in splicing regulation

, 2014
Fused in sarcoma (FUS), also called translocated in liposarcoma (TLS), is a ubiquitously expressed DNA/RNA binding protein belonging to the TET family and predominantly localized in the nucleus.
Ruepp, Marc-David
core