Results 71 to 80 of about 48,475 (224)
The FUS protein is required for cell proliferation [PDF]
, 2013 FUS/TLS (fused in sarcoma/translocated in liposarcoma) protein, a ubiquitously expressed and highly conserved RNA binding protein, has been linked to a variety of cellular processes from mRNA processing to DNA repair. However, the precise function of FUS
Ruepp, Marc-David
core
The Kaohsiung Journal of Medical Sciences, Volume 40, Issue 11, Page 972-984, November 2024.Abstract Septic acute kidney injury (AKI) is a fatal disease in the intensive care unit, with ferroptosis playing a crucial role in its pathogenesis. Long non‐coding RNA (LncRNA) metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) has been implicated in septic‐induced AKI inflammation and apoptosis.
Zhi‐Bing Duan +3 more
wiley +1 more source
Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3 [PDF]
, 2012 Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in ...
Thomsen, Christer
core
, 2021 The objective of this project was to evaluate the ability of Focused Ultrasound (FUS) induced mild local hyperthermia (40-45°C) to enhance doxorubicin (Dox) delivery in sarcoma tumors of veterinary patients.
Ashish Ranjan +4 more
core +1 more source
An ALS-associated mutation in the FUS 3′2-UTR disrupts a microRNA-FUS regulatory circuitry [PDF]
, 2014 While the physiologic functions of the RNA-binding protein FUS still await thorough characterization, the pathonegetic role of FUS mutations in amyotrophic lateral sclerosis (ALS) is clearly established.
Sabatelli M. +4 more
core +3 more sources
Genes, Chromosomes and Cancer, Volume 63, Issue 9, September 2024.ABSTRACT The identification of gene fusions in rare sarcoma subtypes can have diagnostic, prognostic, and therapeutic impacts for advanced cancer patients. Here, we present a case of a 31‐year‐old male with a lytic lesion of the left mandible initially diagnosed as an osteosarcoma but found to have a TFCP2 fusion and ALK alteration, redefining the ...
Veronika Csizmok +9 more
wiley +1 more source
FUS affects splicing of minor introns: Implications for ALS [PDF]
, 2016 Fused in sarcoma (FUS) is a ubiquitously expressed protein of the hnRNP family and has several reported functions in diverse RNA metabolic pathways. Among them regulation of transcription, pre-mRNA splicing, mRNA transport and miRNA processing.
Reber, Stefan
core
Neurobiology of Disease, 2015 Autosomal-dominant mutations within the gene FUS (fused in sarcoma) are responsible for 5% of familial cases of amyotrophic lateral sclerosis (ALS). The FUS protein is physiologically mainly located in the nucleus, while cytoplasmic FUS aggregates are ...
Julia Japtok +12 more
doaj +1 more source
Scientific Reports, 2021 Aberrantly expressed fused in sarcoma (FUS) is a hallmark of FUS-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Wildtype FUS localises to synapses and interacts with mitochondrial proteins while mutations have been shown ...
Shaakir Salam +7 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.Abstract Ferroptosis is a new type of programmed cell death, which has been involved in the progression of tumours. However, the regulatory network of ferroptosis in pancreatic cancer is still largely unknown. Here, using datasets from GEO and TCGA, we screened HSPB1, related to the P450 monooxygenase signalling, a fuel of ferroptosis, to be a ...
Lun Zhang, Liuxu Yang, Keyuan Du
wiley +1 more source