Results 41 to 50 of about 51,631 (223)
Brain Stimulation, 2020 Background: Transcranial focused ultrasound (tFUS) is a noninvasive brain stimulation method that may modulate deep brain structures. This study investigates whether sonication of the right anterior thalamus would modulate thermal pain thresholds in ...
Bashar W. Badran +12 more
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Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
, 2021 International audienceMutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS).
Pérez-Berlanga, Manuela +11 more
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Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS
Frontiers in Molecular Neuroscience, 2021 Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood.
Clara Tejido +4 more
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US-tracked steered FUS in a respiratory ex vivo ovine liver phantom
Current Directions in Biomedical Engineering, 2015 Organ motion is a major problem for Focused Ultrasound Surgery (FUS) of liver tumors. We present a liver phantom mimicking human respiratory motion (20 mm range, 3 − 7 s/cycle) and the evaluation of an ultrasound-tracked steered FUS system on that ...
Strehlow Jan +9 more
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Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. [PDF]
PLoS Biology, 2011 TDP-43 and FUS are RNA-binding proteins that form cytoplasmic inclusions in some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, mutations in TDP-43 and FUS are linked to ALS and FTLD.
Zhihui Sun +6 more
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International Journal of Nanomedicine, 2021 Qiang Yang,1 Yanghao Zhou,1 Jin Chen,1 Ning Huang,1 Zhigang Wang,2 Yuan Cheng1 1Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 2Institute of Ultrasound ...
Yang Q +5 more
doaj
Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3 [PDF]
, 2012 Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in ...
Thomsen, Christer
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Young-Onset Amyotrophic Lateral Sclerosis: Genetic Structure and Phenotypic Features [PDF]
Анналы клинической и экспериментальной неврологииIntroduction. Young-onset amyotrophic lateral sclerosis (yALS) is a rare neurodegenerative disease characterized by the onset of clinical manifestations before the age of 45.
Denis V. Shevchuk +5 more
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FUS Interacts with HSP60 to Promote Mitochondrial Damage. [PDF]
PLoS Genetics, 2015 FUS-proteinopathies, a group of heterogeneous disorders including ALS-FUS and FTLD-FUS, are characterized by the formation of inclusion bodies containing the nuclear protein FUS in the affected patients.
Jianwen Deng +14 more
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