Results 111 to 120 of about 16,368 (183)

Protein Biomarkers in Risk and Prognosis of Amyotrophic Lateral Sclerosis

European Journal of Neurology, Volume 33, Issue 9, September 2026.
ABSTRACT Background Plasma and cerebrospinal fluid (CSF) protein biomarkers in amyotrophic lateral sclerosis (ALS) may provide insight into disease mechanisms and yield clinically useful biomarkers. Methods Overall, 363 proteins in plasma and CSF from 198 patients with ALS and 125 matched controls were profiled using Olink assays.
Lu Pan, Can Hou, Christina Seitz, Caroline Ingre, Åsa K. Hedman, Jose Laffita, Trung Nghia Vu, Yudi Pawitan, Abbe Ullgren, Solmaz Yazdani, John Andersson, Emily E. Joyce, Charilaos Chourpiliadis, Anikó Lovik, Yan Chen, Sebastian A. Lewandowski, Oscar Fernandez‐Capetillo, Myriam Barz, Kristin Samuelsson, Rayomand Press, Fredrik Piehl, Caroline Graff, Anders Mälarstig, Fang Fang   +23 more
wiley   +1 more source

Loss of C9orf72 decreases mTOR activation.

, 2016
A) Immunoblot analysis of mTOR activity after starvation and amino acid stimulation. HEK293T cells were transfected with control or C9orf72 shRNA for 72 hours before treatment.
Justin Chu (732152), Yon Ju Ji (3359057), Janet Ugolino (3359054), Jiou Wang (267956), Karen Conchina (3359060), Akhilesh Pandey (14293), Raja Sekhar Nirujogi (841149), Anne Hamacher-Brady (177723), Nathan R. Brady (51959)   +8 more
core   +1 more source

C9orf72 and intracerebral hemorrhage.

, 2019
The chromosome 9 open reading frame 72 (C9orf72) GGGGCC repeat expansion has been associated with several diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. It has also been associated with increased white matter changes
Shakeshaft, Clare, Werring, David J, Cohen, Hannah, Sharma, Nikhil, Yousry, Tarek, Seiffge, David Julian, Wilson, Duncan, Brown, Martin M, Jäger, Hans R, Wong, Andrew, Houlden, Henry, Hostettler, Isabel C, Muir, Keith W, Lip, Gregory Y H, Bernal-Quiros, Manuel, Al-Shahi Salman, Rustam   +15 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

C9orf72 and SMCR8 form a stable protein complex.

, 2016
A) Schematic representation of SILAC mass spectrometry screen for C9orf72 interacting proteins. Metabolically labeled HEK293T cells expressing Flag-tagged C9orf72 Isoform A (heavy) or non-transfected control cells (light) were incubated with anti-Flag ...
Justin Chu (732152), Yon Ju Ji (3359057), Janet Ugolino (3359054), Jiou Wang (267956), Karen Conchina (3359060), Akhilesh Pandey (14293), Raja Sekhar Nirujogi (841149), Anne Hamacher-Brady (177723), Nathan R. Brady (51959)   +8 more
core   +1 more source

PML as a neuroprotective guardian: Leveraging nuclear protein quality control to mitigate neurotoxicity of an ALS‐associated NEK1 variant

The FEBS Journal, Volume 293, Issue 17, Page 5145-5148, September 2026.
Insoluble protein aggregates are a hallmark of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). The ubiquitin–proteasome system (UPS) serves as a neuroprotective quality control mechanism that clears aggregates. PML nuclear bodies (NBs) were proposed to serve as hubs for SUMO‐primed ubiquitylation and degradation of misfolded ...
Tabea Stark, Stefan Müller
wiley   +1 more source

Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD-1 mutant mice

Journal of Neuroinflammation
Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder where neuromuscular health is central to disease progression.
Francesca Sironi, Massimo Tortarolo, Sabrina Mazzucchi, Laura Camporeale, Mattia Freschi, Eliana Arcadipane, Giulia De Giovanetti, Mami Kurosaki, Mineko Terao, Paola Parlanti, Paola Podini, Francesco Gentile, Valentina Bonetto, Valentina Cappello, Nilo Riva, Angelo Quattrini, Caterina Bendotti   +16 more
doaj   +1 more source

AUG-Dependent Translation of Antisense Repeat Transcripts Contributes to Dipeptide Repeat Protein Production in <i>C9ORF72</i> Expansion Carriers. [PDF]

Cells
Almeida S, Gu Y, Kankel MW.
europepmc   +1 more source

The spectrum of <i>C9orf72</i> repeat lengths in Portuguese frontotemporal dementia and amyotrophic lateral sclerosis patients: from pathogenic expansions to intermediate alleles. [PDF]

Front Neurosci
Almeida MR, Tábuas-Pereira M, Matos A, Santos A, Teixeira C, Baldeiras I, Lima M, Santana I.   +7 more
europepmc   +1 more source

Presymptomatic Amyotrophic Lateral Sclerosis: From Early Biomarker Detection to Phenoconversion Prediction. [PDF]

Diagnostics (Basel)
Chen M, Li H, Jin Q.
europepmc   +1 more source