Results 141 to 150 of about 300,385 (307)

The Dysfunction of Ca²⁺ Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models. [PDF]

Int J Mol Sci, 2023
Shemarova I.
europepmc   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum

Cell Reports
Summary: Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to ...
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel   +13 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Formaldehyde induced the cardiac damage by regulating the NO/cGMP signaling pathway and L-Ca²⁺ channels. [PDF]

Toxicol Res (Camb), 2023
Bai C, Zhang F, Yang Z, Zhang Y, Guo D, Zhang Q.   +5 more
europepmc   +1 more source

Alkaline Leaching: A Facile Surface Activation Strategy to Improve the Reactivity of Air Electrodes for Solid Oxide Fuel Cells

Advanced Materials, EarlyView.
This study shows that alkaline leaching of PrBa0.8Ca0.2Co2O5+δ under anodic bias selectively removes Ba and Ca, forming a cobalt‐rich and amorphous layer. The modified surface significantly boosts ORR activity, offering a simple and effective strategy to improve electrochemical device performance.
Yeongtaek Hong, Hyunseung Kim, Sang Won Lee, Yong Beom Kim, SungHyun Jeon, Sangwoo Kim, Hainan Sun, Jeongah Lee, Seongwoo Nam, Seungwoo Roh, Tae Ho Shin, WooChul Jung   +11 more
wiley   +1 more source

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm. [PDF]

Hum Reprod, 2021
Rahban R, Rehfeld A, Schiffer C, Brenker C, Egeberg Palme DL, Wang T, Lorenz J, Almstrup K, Skakkebaek NE, Strünker T, Nef S.   +10 more
europepmc   +1 more source

Opportunities of Semiconducting Oxide Nanostructures as Advanced Luminescent Materials in Photonics

Advanced Materials, EarlyView.
The review discusses the challenges of wide and ultrawide bandgap semiconducting oxides as a suitable material platform for photonics. They offer great versatility in terms of tuning microstructure, native defects, doping, anisotropy, and micro‐ and nano‐structuring. The review focuses on their light emission, light‐confinement in optical cavities, and
Ana Cremades, Pedro Hidalgo, David Maestre, Ruth Martínez‐Casado, Emilio Nogales, Beatriz Rodríguez, G. Cristian Vásquez, Bianchi Méndez   +7 more
wiley   +1 more source

Functional tuning of Vascular L-type Ca²⁺ channels. [PDF]

Front Physiol, 2022
Mironova GY, Haghbin N, Welsh DG.
europepmc   +1 more source