Results 161 to 170 of about 192,611 (304)

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

L-type voltage-gated Ca²⁺ channels control T cell killing via non-canonical Hedgehog signalling. [PDF]

EMBO Rep
Beke F, Hanna J, Kapeni C, Carbonaro V, Mueller N, Trotter S, Chilamakuri C, O'Brien LM, de la Roche M.   +8 more
europepmc   +1 more source

Feed-forward metabotropic signaling by Cav1 Ca²⁺ channels supports pacemaking in pedunculopontine cholinergic neurons. [PDF]

Neurobiol Dis, 2023
Tubert C, Zampese E, Pancani T, Tkatch T, Surmeier DJ.   +4 more
europepmc   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress. [PDF]

J Cell Biol
Feng X, Cai W, Li Q, Zhao L, Meng Y, Xu H.   +5 more
europepmc   +1 more source

Flexoelectricity in Photoconversion: Fundamentals, Materials, and Outlooks

Advanced Science, EarlyView.
Mechanical bending of a flexible cantilever induces a strain gradient in the photoactive material. The resulting flexoelectric field couples with photovoltaic and photoconductive effects, modulating charge generation, separation, and collection. A comparative analysis of oxide perovskites, halide perovskites, and two‐dimensional materials is presented,
Xiang Huang, Feng Li, Rongkun Zheng
wiley   +1 more source

Bottom-up design of Ca²⁺ channels from defined selectivity filter geometry. [PDF]

Nature
Liu Y, Weidle C, Mihaljević L, Watson JL, Li Z, Yu LT, Majumder S, Borst AJ, Carr KD, Kibler RD, Gamal El-Din TM, Catterall WA, Baker D.   +12 more
europepmc   +1 more source

Diabetes-Induced Amplification of Nociceptive DRG Neuron Output by Upregulation of Somatic T-Type Ca²⁺ Channels. [PDF]

Biomolecules, 2023
Ivasiuk A, Matvieienko M, Kononenko NI, Duzhyy DE, Korogod SM, Voitenko N, Belan P.   +6 more
europepmc   +1 more source

Lattice Distortion‐Driven Metal Exsolution in Perovskite Oxides

Advanced Science, EarlyView.
This study elucidates the mechanism of lattice distortion‐driven exsolution through a combination of computational simulations and experimental approaches. Lattice distortion facilitates the formation of oxygen vacancies and subsequent metal segregation, thereby enhancing the exsolution behavior.
Yo Han Kim, Uchan Jeon, Hyeongwon Jeong, Bo‐Ram Won, Jeong Woo Han, Jae‐ha Myung   +5 more
wiley   +1 more source

L-Type Voltage-Gated Ca²⁺ Channels Are Targeted by Terpenes from <i>Hyptis crenata</i> Essential Oil in Vascular Electromechanical Coupling. [PDF]

Med Sci (Basel)
Cardeal Dos Santos AN, da Cruz Freire JE, Henrique Félix FS, Araújo MC, Gomes SML, Cabral ALLF, Nascimento AB, Barbosa CC, Vieira Torquato MV, Oliveira LS, Assunção LHB, Brasil SMS, Freitas CB, da Silva JF, Menezes JHA, Pereira-Gonçalves Á, Leal-Cardoso JH, Aquino AJA, Coelho de Sousa AN.   +18 more
europepmc   +1 more source