Results 71 to 80 of about 192,611 (304)

Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells.

, 2005
NIH: HL55426 y AI058173 Interdisciplinary Training Program in Muscle Biology, University of Maryland School of MedicineThe ubiquitously expressed canonical transient receptor potential (TRPC) ion channels are considered important in Ca2+ signal ...
Spassova, Maria, Soboloff, Jonathan, Wen, Xu, Cuesta Rubio, Natalia, Gill, Donald, Li-Ping, He   +5 more
core   +1 more source

Chemical Control of Space Charge Barriers and Grain Boundary Resistances in Polycrystalline Ionic Conductors

Advanced Functional Materials, EarlyView.
Grain boundaries (GBs) in polycrystalline materials often block charge transport and drive degradation. Using Gd‐doped CeO2 as a model electrolyte used in fuel/electrolysis cells, we developed a core‐shell infiltration method to selectively modify GB chemistry and space charge potential, achieving orders‐of‐magnitude ionic conductivity changes.
Z. Sha, T. Defferriere, C. Gilgenbach, J. M. LeBeau, I. Lubomirsky, H. L. Tuller   +5 more
wiley   +1 more source

Pathophysiological Significance of T-type Ca2+ Channels: Role of T-type Ca2+ Channels in Renal Microcirculation

Journal of Pharmacological Sciences, 2005
Since conventional Ca2+ antagonists, with predominant blockade of L-type voltage-dependent Ca2+ channels, elicit preferential dilation of afferent arterioles, they might ostensibly aggravate glomerular hypertension. Recently, novel Ca2+ antagonists, with
Koichi Hayashi, Shu Wakino, Koichiro Homma, Naoki Sugano, Takao Saruta   +4 more
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

Engineering Local Polar Frustration in Lead‐Free Dielectric Ceramics for Ultrahigh Normalized Energy Storage Performance

Advanced Functional Materials, EarlyView.
Local polar frustration is engineered to stabilize an ergodic relaxer through nanoscale multiphase coexistence, suppressing long‐range ferroelectric order while preserving high polarization. This strategy delivers ultrahigh low‐field normalized energy density (Wa >0.020 mC cm−2), exceptional thermal stability, and a transferable design principle for ...
Hareem Zubairi, Muhammad Wasim, Songhao Fu, Xiaojiao Liu, Annette K Kleppe, Zhilun Lu, Antonio Feteira, Diming Xu, Joseph C.A. Prentice, Ge Wang   +9 more
wiley   +1 more source

Ca2+/Calcineurin-Dependent Inactivation of Neuronal L-Type Ca2+ Channels Requires Priming by AKAP-Anchored Protein Kinase A

Cell Reports, 2014
Within neurons, Ca2+-dependent inactivation (CDI) of voltage-gated L-type Ca2+ channels shapes cytoplasmic Ca2+ signals. CDI is initiated by Ca2+ binding to channel-associated calmodulin and subsequent Ca2+/calmodulin activation of the Ca2+-dependent ...
Philip J. Dittmer, Mark L. Dell’Acqua, William A. Sather   +2 more
doaj   +1 more source

Calcium Oscillations in Pancreatic α-cells Rely on Noise and ATP-Driven Changes in Membrane Electrical Activity

Frontiers in Physiology, 2020
In pancreatic α-cells, intracellular Ca2+ ([Ca2+]i) acts as a trigger for secretion of glucagon, a hormone that plays a key role in blood glucose homeostasis.
Virginia González-Vélez, Anthony Piron, Anthony Piron, Geneviève Dupont, Geneviève Dupont   +4 more
doaj   +1 more source

Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks

Advanced Functional Materials, EarlyView.
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran, Kalyan Shobhana, Zlatan Trifunovic, Dan Smith, Michael Stuiber, Chennupati Jagadish, Mirella Dottori, Andrea J. O'Connor, Vini Gautam   +8 more
wiley   +1 more source

Key role for store-operated Ca2+ channels in activating gene expression in human airway bronchial epithelial cells.

PLoS ONE, 2014
Ca2+ entry into airway epithelia is important for activation of the NFAT family of transcription factors and expression of genes including epidermal growth factor that help orchestrate local inflammatory responses. However, the identity of epithelial Ca2+
Krishna Samanta, Daniel Bakowski, Anant B Parekh   +2 more
doaj   +1 more source

STIM and Orai1 variants in store-operated calcium entry

Frontiers in Pharmacology, 2016
Store-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM ...
JUAN ANTONIO ROSADO, Raquel eDiez, Tarik eSmani, Isaac eJardin   +3 more
doaj   +1 more source