Results 231 to 240 of about 245,889 (266)

Mitochondria in Ca2+ Signaling and Apoptosis

Journal of Bioenergetics and Biomembranes, 2000
Cellular Ca2+ signals are crucial in the control of most physiological processes, cell injury and programmed cell death; mitochondria play a pivotal role in the regulation of such cytosolic Ca2+ ([Ca2+]c) signals. Mitochondria are endowed with multiple Ca2+ transport mechanisms by which they take up and release Ca2+ across their inner membrane.
S S, Smaili, Y T, Hsu, R J, Youle, J T, Russell   +3 more
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NAADP-Mediated Ca2+ Signalling

2022
The discovery of NAADP-evoked Ca2+ release in sea urchin eggs and then as a ubiquitous Ca2+ mobilizing messenger has introduced several novel paradigms to our understanding of Ca2+ signalling, not least in providing a link between cell stimulation and Ca2+ release from lysosomes and other acidic Ca2+ storage organelles.
Antony, Galione, Lianne C, Davis, Lora L, Martucci, Anthony J, Morgan   +3 more
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Ca2+ Signaling in Oligodendrocyte Development

Cellular and Molecular Neurobiology, 2019
Calcium signaling has essential roles in the development of the nervous system, from neural induction to the proliferation, migration, and differentiation of both neuronal and glia cells. The temporal and spatial dynamics of Ca2+ signals control the highly diverse yet specific transcriptional programs that establish the complex structures of the ...
Ming, Zhang, Yuming, Liu, Shengxi, Wu, Xianghui, Zhao   +3 more
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Ca2+ to the rescue – Ca2+channels and signaling in plant immunity

Plant Science, 2019
Ca2+ is a universal second messenger in many signaling pathways in all eukaryotes including plants. Transient changes in [Ca2+]cyt are rapidly generated upon a diverse range of stimuli such as drought, heat, wounding, and biotic stresses (infection by pathogenic and symbiotic microorganisms), as well as developmental cues. It has been known for a while
Wolfgang Moeder, Van Phan, Keiko Yoshioka   +2 more
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Ca2+ Signaling, Mitochondria and Cell Death

Current Molecular Medicine, 2008
In the complex interplay that allows different signals to be decoded into activation of cell death, calcium (Ca2+) plays a significant role. In all eukaryotic cells, the cytosolic concentration of Ca2+ ions ([Ca2+]c) is tightly controlled by interactions among transporters, pumps, channels and binding proteins.
GIORGI, Carlotta, ROMAGNOLI, Anna, PINTON, Paolo, RIZZUTO, Rosario   +3 more
openaire   +4 more sources

Ca2+ Signaling in the Pancreatic Acinus

Pancreas, 1998
Change in cytosolic free calcium ion concentration [Ca2+]c, resulting from receptor activation by an appropriate agonist, functions as a cardinal intracellular signaling in the stimulus-secretion coupling in a wide variety of secretory cells including the acini of the pancreas.
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Ca2+ Signaling in T-Lymphocytes

Critical Reviews™ in Immunology, 1998
Ca2+ signaling in response to antigenic stimulation is essential for proliferation of T cells and therefore is one of the important early events in T-lymphocyte signal transduction. Several aspects of T cell receptor/CD3 complex stimulated Ca2+ signaling are reviewed: generation, metabolism, function, and intracellular targets of the Ca(2+)-mobilizing ...
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Ligand-gated Ca2+ channels and Ca2+ signalling in higher plants

Journal of Experimental Botany, 1997
Ligand-gated Ca(2+) channels provide a possible mechanism for linking perception of stimuli to intracellular Ca(2+) mobilization. Evidence for ligand-gated Ca(2+) release in plant cells arises from radiolabeled ligand binding, microsomal ion flux, and electrophysiological approaches. Results from these diverse approaches demonstrate that two classes of
S R, Muir, M A, Bewell, D, Sanders, G J, Allen   +3 more
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Mitochondrial Ca2+ Signalling

1998
Historically, the role played by mitochondria in cellular Ca2+ homeostasis has been the subject of considerable controversy (Fiskum & Lehninger, 1982; Akerman & Nicholls, 1983). The view that mitochondria, by virtue of possessing a huge capacity for Ca2+ uptake (Lehninger, 1967) act in the cell as mobilizable stores of the ion (Exton, 1980) capable of ...
Guy A. Rutter, Paul Burnett, Lawrence D. Robb-Gaspers, Andrew P. Thomas, Richard M. Denton, Elinor J. Griffiths, Rosario Rizzuto   +6 more
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Mitochondrial VDAC, the Na+/Ca2+ Exchanger, and the Ca2+ Uniporter in Ca2+ Dynamics and Signaling

2017
Mitochondrial Ca2+ uptake and release play pivotal roles in cellular physiology by regulating intracellular Ca2+ signaling, energy metabolism, and cell death. Ca2+ transport across the inner and outer mitochondrial membranes (IMM, OMM, respectively), is mediated by several proteins, including the voltage-dependent anion channel 1 (VDAC1) in the OMM ...
Varda, Shoshan-Barmatz, Soumasree, De
openaire   +2 more sources