Results 161 to 170 of about 284,314 (352)
T-cadherin loss promotes experimental metastasis of squamous cell carcinoma
, 2013 T-cadherin is gaining recognition as a determinant for the development of incipient invasive squamous cell carcinoma (SCC). However, effects of T-cadherin expression on the metastatic potential of SCC have not been studied.
Resink, T. J. +17 more
core +1 more source
Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays
Advanced Science, EarlyView.ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen +13 more
wiley +1 more source
Blood serum levels of E-cadherin in patients with colorectal cancer
, 2017 Introduction : Colorectal cancer is the second most common cancer in terms of incidence in Poland. It is also the second most common cause of cancer deaths in men and the third women.
Konrad Zaręba +7 more
core +1 more source
Advanced Science, EarlyView.This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen +7 more
wiley +1 more source
, 2011 chromosome 5; the right part shows the relative position of all genes studied that are located in this chromosome and that were amplified. The arrows indicate their transcription orientation and the values in parentheses under the names correspond to ...
Cristina Morales (83591) +4 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon +20 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du +15 more
wiley +1 more source
, 2016 (LEFT) Sensitivity to changes in individual reactions of fold-change (upon activation of Wnt/β-catenin signaling) in β-catenin, DPAGT1 mRNA and GPT, AJ, and E-cadherin adhesivity at steady-state. Reaction labels refer to numbering used in Fig 2; repeated
Muhammad H. Zaman (203839) +4 more
core +1 more source
Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy
Advanced Science, EarlyView.A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru +2 more
wiley +1 more source
, 2011 Romosomal location. The names for all the genes studied are depicted on top of their chromosome position. Red is used to color the overexpressed genes and blue is used to highlight the underexpressed genes.Copyright information:Taken from "Role of ...
Cristina Morales (83591) +3 more
core +1 more source