Results 21 to 30 of about 305,587 (238)

TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. [PDF]

, 2016
E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum ...
Barcellos-Hoff, MH, He, YY, Qiang, L, Shah, P   +3 more
core   +1 more source

Holding it together: when cadherin meets cadherin

Biophysical Journal, 2021
Intercellular adhesion is the key to multicellularity, and its malfunction plays an important role in various developmental and disease-related processes. Although it has been intensively studied by both biologists and physicists, a commonly accepted definition of cell-cell adhesion is still being debated.
Arslan, F.N., Eckert, J., Schmidt, T., Heisenberg, C.P.   +3 more
openaire   +4 more sources

Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity

Frontiers in Cell and Developmental Biology, 2023
Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis. Like its Drosophila ortholog, Flamingo, mammalian
Lena P. Basta, Parijat Sil, Rebecca A. Jones, Katherine A. Little, Gabriela Hayward-Lara, Gabriela Hayward-Lara, Danelle Devenport   +6 more
doaj   +1 more source

Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue [PDF]

, 2015
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent ...
Anderson, Kurt I., Campbell, Andrew D., Conway, James R.W., Croucher, David R., Erami Rud Majani, Zahra, Evans, T.R. Jeffry, Gallego-Ortega, David, Grey, Shane T., Gunning, Peter W., Hardeman, Edna C., Herrmann, David, Herzog, Herbert, Kadir, Shereen, Karim, Saadia A., Law, Andrew M., Leung, Wilfred, Lucas, Morghan C., Magenau, Astrid, McGhee, Ewan J., Morton, Jennifer P., Mrowinska, Agata, Murphy, Kendelle J., Nobis, Max, Ormandy, Christopher J., Reischmann, Nadine, Ridgway, Rachel A., Sansom, Owen J., Schwarz, Juliane P., Strathdee, Douglas, Timpson, Paul, Vennin, Claire, Walters, Stacey N., Warren, Sean C., Zhang, Lei   +33 more
core   +2 more sources

Molecular Genetic Basis of Lab- and Field-Selected Bt Resistance in Pink Bollworm

Insects, 2023
Transgenic crops producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) control some important insect pests. However, evolution of resistance by pests reduces the efficacy of Bt crops. Here we review resistance to Bt cotton in the
Jeffrey A. Fabrick, Xianchun Li, Yves Carrière, Bruce E. Tabashnik   +3 more
doaj   +1 more source

Zebrafish teeth as a model for repetitive epithelial morphogenesis: dynamics of E-cadherin expression [PDF]

, 2010
Background: The development of teeth is the result of interactions between competent mesenchyme and epithelium, both of which undergo extensive morphogenesis.
Huysseune, Ann, Sanders, Ellen, van Hengel, Jolanda, Verstraeten, Barbara   +3 more
core   +3 more sources

Quantification of the stiffness and strength of cadherin ectodomain binding with different ions

Theoretical and Applied Mechanics Letters, 2014
The stiffness and strength of extracellular (EC) region of cadherin are proposed to be two important mechanical properties both for cadherin as a mechanotransductor and for the formation of cell-cell adhesion.
Zhiyang Xu, Dechang Li, Ji Baohua
doaj   +1 more source

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] [PDF]

, 2004
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Arthur, Michael J.P., Benyon, R. Christopher, Collins, Jane, Iredale, John P., Mann, Derek, Murphy, Frank, Nagase, Hideaki, Waung, Julian   +7 more
core   +2 more sources

Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential

Frontiers in Oncology, 2022
Neuroblastoma, a biologically heterogeneous tumor derived from neural crest cells, accounts for approximately 15% of childhood deaths from cancer.
Briana E. Heinly, Christa N. Grant, Christa N. Grant   +2 more
doaj   +1 more source

Identification of a novel human E-Cadherin splice variant andassessment of its effects upon EMT-related events [PDF]

, 2018
Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor progression.
Besso, María José, Furlong, Laura Ines, Giustina, Silvina, Lapyckyj, Lara, Marin Briggiler, Clara Isabel, Matos, María Laura, Mencucci, Maria Victoria, Rosso, Marina, Vazquez, Monica Hebe   +8 more
core   +1 more source