Results 41 to 50 of about 284,314 (352)
Frontiers in Oncology, 2020 SIRT7 belongs to the family of “NAD+ dependent deacetylases” called Sirtuins. In the present work we report a novel role of SIRT7 in regulating cellular polarity.
Shashi Kiran +4 more
doaj +1 more source
Desmoglein-2 as a cancer modulator: friend or foe?
Frontiers in Oncology, 2023 Desmoglein-2 (DSG2) is a calcium-binding single pass transmembrane glycoprotein and a member of the large cadherin family. Until recently, DSG2 was thought to only function as a cell adhesion protein embedded within desmosome junctions designed to enable
Kay K. Myo Min +13 more
doaj +1 more source
, 2004 Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael +11 more
core +1 more source
Travelling to Rome : inflammation, endoplasmic reticulum stress and angiogenesis during atherosclerotic plaque development [PDF]
, 2010 Cardiovascular diseases are the leading cause of death worldwide followed by cancer. Atherosclerosis, the major underlying cause of cardiovascular diseases, is a syndrome affecting medium-sized and large arteries.
Kyriakakis, Emmanouil
core +1 more source
Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells
Cell Reports, 2017 Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and ...
Aviva J. Goel +4 more
doaj +1 more source
Cells, 2022 Cell–cell junctions are pivotal for embryogenesis and tissue homeostasis but also play a major role in tumorigenesis, tumor invasion, and metastasis. E-cadherin (CDH1) and N-cadherin (CDH2) are two adherens junction’s transmembrane glycoproteins with ...
Tiemo Sven Gerber +10 more
doaj +1 more source
Holding it together: when cadherin meets cadherin
Biophysical Journal, 2021 Intercellular adhesion is the key to multicellularity, and its malfunction plays an important role in various developmental and disease-related processes. Although it has been intensively studied by both biologists and physicists, a commonly accepted definition of cell-cell adhesion is still being debated.
Arslan, F.N. +3 more
openaire +5 more sources
Image_1_Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src.TIF
, 2020 Activity of heparanase, responsible for cleavage of heparan sulfate (HS), is strongly implicated in tumor metastasis. This is due primarily to remodeling of the extracellular matrix (ECM) that becomes more prone to invasion by metastatic tumor cells.
Neta Ilan (48778) +2 more
core +1 more source
, 2023 BackgroundThe cell adhesion molecule (CAM) N-cadherin has become an important target for tumor therapy. The N-cadherin antagonist, ADH-1, exerts significant antitumor activity against N-cadherin-expressing cancers.MethodsIn this study, [18F]AlF-NOTA-ADH ...
Zhenfeng Liu (431113) +23 more
core +1 more source
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Nature Cell Biology, 2010 MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased ...
Li Ma +13 more
semanticscholar +1 more source