Results 21 to 30 of about 187,124 (218)

Dynamic Expression and Functional Implications of the Cell Polarity Gene, Dchs1, During Cardiac Development

Cells
Intercellular interactions among cardiac cell populations are essential for cardiac morphogenesis, yet the molecular mechanisms orchestrating these events remain incompletely understood.
Kathryn Byerly, Cayla Wolfe, Hannah Parris, Charlotte Griggs, Emily Wilson, Matthew Huff, Molly Griggs, Jordan Morningstar, Lilong Guo, Fulei Tang, Jan Guz, Taylor Petrucci, Ranan Phookan, Brian Loizzi, Cortney Gensemer, Russell A. Norris   +15 more
doaj   +1 more source

Cadherin Protein Is Involved in the Action of Bacillus thuringiensis Cry1Ac Toxin in Ostrinia furnacalis

Toxins, 2021
Transgenic crops expressing Bacillus thuringiensis (Bt) insecticidal proteins have been extensively planted for insect pest control, but the evolution of Bt resistance in target pests threatens the sustainability of this approach.
Wenzhong Jin, Yuqian Zhai, Yihua Yang, Yidong Wu, Xingliang Wang   +4 more
doaj   +1 more source

Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization

Frontiers in Oncology, 2020
SIRT7 belongs to the family of “NAD+ dependent deacetylases” called Sirtuins. In the present work we report a novel role of SIRT7 in regulating cellular polarity.
Shashi Kiran, Shashi Kiran, Manjari Kiran, Manjari Kiran, Gayatri Ramakrishna   +4 more
doaj   +1 more source

Desmoglein-2 as a cancer modulator: friend or foe?

Frontiers in Oncology, 2023
Desmoglein-2 (DSG2) is a calcium-binding single pass transmembrane glycoprotein and a member of the large cadherin family. Until recently, DSG2 was thought to only function as a cell adhesion protein embedded within desmosome junctions designed to enable
Kay K. Myo Min, Charlie B. Ffrench, Barbara J. McClure, Barbara J. McClure, Michael Ortiz, Emma L. Dorward, Michael S. Samuel, Michael S. Samuel, Michael S. Samuel, Lisa M. Ebert, Lisa M. Ebert, Mỹ G. Mahoney, Claudine S. Bonder, Claudine S. Bonder   +13 more
doaj   +1 more source

Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells

Cell Reports, 2017
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and ...
Aviva J. Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L. Radice, Robert S. Krauss   +4 more
doaj   +1 more source

Constitutive Occurrence of E:N-cadherin Heterodimers in Adherens Junctions of Hepatocytes and Derived Tumors

Cells, 2022
Cell–cell junctions are pivotal for embryogenesis and tissue homeostasis but also play a major role in tumorigenesis, tumor invasion, and metastasis. E-cadherin (CDH1) and N-cadherin (CDH2) are two adherens junction’s transmembrane glycoproteins with ...
Tiemo Sven Gerber, Dirk Andreas Ridder, Mario Schindeldecker, Arndt Weinmann, Diane Duret, Kai Breuhahn, Peter R. Galle, Peter Schirmacher, Wilfried Roth, Hauke Lang, Beate Katharina Straub   +10 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Binding and Synergizing Motif within Coleopteran Cadherin Enhances Cry3Bb Toxicity on the Colorado Potato Beetle and the Lesser Mealworm

Toxins, 2019
Cry3Bb toxin from Bacillus thuringiensis is an important insecticidal protein due to its potency against coleopteran pests, especially rootworms. Cadherin, a protein in the insect midgut epithelium, is a receptor of Cry toxins; in some insect species ...
Youngjin Park, Gang Hua, Suresh Ambati, Milton Taylor, Michael J. Adang   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Matrix metalloproteinases, synaptic injury, and multiple sclerosis

Frontiers in Psychiatry, 2010
Multiple sclerosis (MS) is a disease of the central nervous system in which immune mediated damage to myelin is characteristic. For an overview of this condition and its pathophysiology, please refer to one of many excellent published reviews. To follow,
Arek Szklarczyk, Katherine eConant
doaj   +1 more source