Results 21 to 30 of about 284,314 (352)

The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda

Toxins, 2020
It is well known that insect larval midgut cadherin protein serves as a receptor of Bacillus thuringiensis (Bt) crystal Cry1Ac or Cry1Ab toxins, since structural mutations and downregulation of cad gene expression are linked with resistance to Cry1Ac ...
Jianfeng Zhang, Minghui Jin, Yanchao Yang, Leilei Liu, Yongbo Yang, Isabel Gómez, Alejandra Bravo, Mario Soberón, Yutao Xiao, Kaiyu Liu   +9 more
doaj   +1 more source

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger   +37 more
core   +1 more source

Regulation of α-catenin conformation at cadherin adhesions

Journal of Biomechanical Science and Engineering, 2018
Cells in our body utilize a variety of adaptor proteins for transmitting context specific signals that arise from the cellular microenvironment. Adaptor proteins lack enzymatic activity and typically perform their function by acting as scaffolds that ...
Kabir H BISWAS
doaj   +1 more source

The FAT1 Cadherin Drives Vascular Smooth Muscle Cell Migration

Cells, 2023
Vascular smooth muscle cells (VSMCs) are normally quiescent and non-migratory, regulating the contraction and relaxation of blood vessels to control the vascular tone.
Dario F. Riascos-Bernal, Gaia Ressa, Anish Korrapati, Nicholas E. S. Sibinga   +3 more
doaj   +1 more source

E-cadherin is required for metastasis in multiple models of breast cancer

Nature, 2019
Metastasis is the major driver of death in patients with cancer. Invasion of surrounding tissues and metastasis have been proposed to initiate following loss of the intercellular adhesion protein, E-cadherin1,2, on the basis of inverse correlations ...
Veena Padmanaban, Ilona Krol, Yasir Suhail, B. Szczerba, N. Aceto, J. Bader, A. Ewald   +6 more
semanticscholar   +1 more source

T-cadherin signaling in endothelial cells [PDF]

, 2007
The cadherin superfamily comprises transmembrane glycoproteins that mediate calciumdependent homophilic cell-cell adhesion. In addition to their pivotal role in mechanical adhesion between cells, cadherins have multiple functions in tissue ...
Joshi, Manjunath B
core   +1 more source

Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin

Cell Host and Microbe, 2013
SUMMARY Fusobacterium nucleatum (Fn) has been associated with colorectal cancer (CRC), but causality and underlying mechanisms remain to be established.
M. Rubinstein, Xiaowei Wang, Wendy Liu, Yujun Hao, G. Cai, Yiping W Han   +5 more
semanticscholar   +1 more source

The cadherin superfamily [PDF]

WormBook, 2005
The cadherins are a major class of membrane proteins with prominent roles in cell adhesion, and the regulation of tissue organisation and morphogenesis. The C. elegans genome encodes 13 cadherins, including representatives of the major cadherin sub-types that are conserved between insects and vertebrates: the so-called classic, Fat-like, Flamingo and ...
openaire   +2 more sources

E-cadherin in Contact Inhibition and Cancer

Oncogene, 2018
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells
Alisha M. Mendonsa, T. Na, B. Gumbiner
semanticscholar   +1 more source

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

Nature Cell Biology, 2017
Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion.
Anna Labernadie, Takuya Kato, A. Brugues, Xavier Serra-Picamal, S. Derzsi, E. Arwert, A. Weston, Víctor González-Tarragó, Alberto Elosegui-Artola, L. Albertazzi, J. Alcaraz, Pere Roca-Cusachs, E. Sahai, X. Trepat   +13 more
semanticscholar   +1 more source