Results 51 to 60 of about 302,660 (297)

Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]

, 2016
BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S, Buccella, Valentina, CALO', LORENZO, Caroccia, Brasilina, Gioco, Francesca, Guerzoni, Eugenia, GUIDOLIN, DIEGO, Montini, Barbara, Pagnin, Elisa, Petrelli, Lucia, Piazza, Maria, Ravarotto, Verdiana, ROSSI, GIANPAOLO, SECCIA, TERESA MARIA   +13 more
core   +1 more source

Differential Displacement of Classical Cadherins by VE-Cadherin [PDF]

Cell Communication & Adhesion, 2002
VE-cadherin is an endothelial cell-specific, type II classical cadherin that plays an important role in permeability, vasculogenesis, and vascular remodeling. Endothelial cells express equal levels of VE- and N-cadherin; VE-cadherin is present injunctions while N-cadherin is diffusely expressed over the surface of the cell.
Meena, Jaggi, Margaret J, Wheelock, Keith R, Johnson   +2 more
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Molecular Genetic Basis of Lab- and Field-Selected Bt Resistance in Pink Bollworm

Insects, 2023
Transgenic crops producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) control some important insect pests. However, evolution of resistance by pests reduces the efficacy of Bt crops. Here we review resistance to Bt cotton in the
Jeffrey A. Fabrick, Xianchun Li, Yves Carrière, Bruce E. Tabashnik   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genomic Locus Modulating IOP in the BXD RI Mouse Strains

G3: Genes, Genomes, Genetics, 2018
Intraocular pressure (IOP) is the primary risk factor for developing glaucoma, yet little is known about the contribution of genomic background to IOP regulation.
Rebecca King, Ying Li, Jiaxing Wang, Felix L. Struebing, Eldon E. Geisert   +4 more
doaj   +1 more source

Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner. [PDF]

, 2015
Objective:Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene.
Afaq, Ahmed, An, An, An, An, An, Baba, Bosniak, DeSantis, Figlin, Hollingsworth, Koyama, Lamb, Mori, Oya, Oya, Rasheed, Rendon, Rettig, Schubert, Seeram, Semenza, Siegel, Smith, Thomas, Volpe, Wehle, Yang   +28 more
core   +2 more sources

CDH17 (cadherin 17, LI cadherin (liver-intestine)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on CDH17 (cadherin 17, LI cadherin (liver-intestine)), with data on DNA, on the protein encoded, and where the gene is implicated.
Rong, Y, Lee, NP, Luk, JM
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

N-cadherin induces partial differentiation of cholinergic presynaptic terminals in heterologous cultures of brainstem neurons and CHO cells

Frontiers in Synaptic Neuroscience, 2012
N-cadherin is a calcium-sensitive cell adhesion molecule commonly expressed at synaptic junctions and contributes to formation and maturation of synaptic contacts.
Richard J Flannery, Juan L Brusés, Juan L Brusés   +2 more
doaj   +1 more source