Results 71 to 80 of about 284,314 (352)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Exchangeable Copper–Zinc Ratio Links Sex Hormones, Tumor Burden, and Epithelial Remodeling in Colorectal Cancer

Biomolecules
Copper (Cu)–zinc (Zn) imbalance has been implicated in colorectal cancer (CRC). Exchangeable copper (exCu), the labile circulating Cu fraction, may better reflect functionally relevant metal dysregulation than total Cu.
Rosanna Squitti, Anastasia De Luca, Altea Severino, Gianluca Rizzo, Luca Emanuele Amodio, Federica Marzi, Gabriella Vicano, Mauro Cozzolino, Angela Lombardi, Mauro Rongioletti, Vincenzo Tondolo   +10 more
doaj   +1 more source

E-cadherin-null mESCs fail to maintain cellular aggregation and show defects in differentiation.

, 2016
(A) Scheme of the isolation and Cre-mediated recombination of Ecadhfl/fl mESCs leading to E-cadherin-null mESCs. (B) Morphology and immunostaining for E-cadherin and p120ctn of E-cadherin-floxed (Ecadhfl/fl, control) and E-cadherin-null (Ecadh-/-) mESCs ...
Marc P. Stemmler (176442), Tim Pieters (3074160), Dagmar Wirth (48093), Vanessa Andries (74590), Danny Huylebroeck (124349), Kelly Lemeire (3074157), Jody J. Haigh (426911), Riet De Rycke (416524), Jolanda van Hengel (253211), Agata Stryjewska (469825), Frans van Roy (3074154), Lieven Haenebalcke (734219), Geert Berx (12850), Steven Goossens (426910), Tino Hochepied (493717)   +14 more
core   +1 more source

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

Molecular Cancer, 2017
Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature.
Daniel Delgado-Bellido, Santiago Serrano-Sáenz, Mónica Fernández-Cortés, F. Oliver   +3 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

CDH2 and CDH13 as potential prognostic and therapeutic targets for adrenocortical carcinoma

Cancer Biology & Therapy
Cadherin 2 (CDH2, N-cadherin) and cadherin 13 (CDH13, T-cadherin, H-cadherin) affect the progress and prognoses of many cancers. However, their roles in adrenocortical carcinoma (ACC), a rare endocrine cancer, remain unclear.
Yongli Situ, Li Deng, Ziqing Huang, Xiaoli Jiang, Liubing Zhao, Juying Zhang, Lingling Lu, Quanyan Liang, Qinying Xu, Zheng Shao, Meng Liang   +10 more
doaj   +1 more source

BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin

, 2020
The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2.
Rahul Pal (116599), Sonam Verma (4818036), Satish Kumar Gupta (8332476), Amandeep Kaur Kang (8332473)   +3 more
core   +1 more source

Extending the host range of Listeria monocytogenes by rational protein design [PDF]

, 2007
In causing disease, pathogens outmaneuver host defenses through a dedicated arsenal of virulence determinants that specifically bind or modify individual host molecules. This dedication limits the intruder to a defined range of hosts.
Wollert, Thomas, Gruber, A.D., Heinz, D.W., Pasche, Bastian, van den Heuvel, Joop, Heinz, Dirk W., Lengeling, A., Gruber, Achim D., Heinz, Dirk W, van den Heuvel, J., Schubert, W.D., Rochon, M., Rochon, Maike, Schubert, Wolf-Dieter, Pasche, B., Lengeling, Andreas, Deppenmeier, Stefanie, Deppenmeier, S., Gruber, Achim D, Wollert, T.   +19 more
core   +1 more source

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

Nature Communications, 2018
During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting
Girish R. Kale, Xingbo Yang, J. Philippe, Madhav Mani, P. Lenne, Thomas Lecuit   +5 more
semanticscholar   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source