Results 81 to 90 of about 284,314 (352)

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

Cell Reports, 2022
Summary: The mechanically activated Piezo channel plays a versatile role in conferring mechanosensitivity to various cell types. However, how it incorporates its intrinsic mechanosensitivity and cellular components to effectively sense long-range ...
Jing Wang, Jinghui Jiang, Xuzhong Yang, Gewei Zhou, Li Wang, Bailong Xiao   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum

eLife, 2022
Cadherins contribute to the organization of nearly all tissues, but the functions of several evolutionarily conserved cadherins, including those of calsyntenins, remain enigmatic.
Zhihui Liu, Man Jiang, Kif Liakath-Ali, Alessandra Sclip, Jaewon Ko, Roger Shen Zhang, Thomas C Südhof   +6 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Modulation of Intercellular Junction by Utilization of Cadherin Peptides as an Effort to Improve Drug Delivery

Makara Seri Sains, 2004
Rapid advances in combinatorial chemistry and molecular biology has influenced the discovery of many proteins, peptides and peptidomimetics as potential therapeutic agents.
Usman Sumo Friend Tambunan, Irwan Makagiansar, Mike Avery, Seetharama D.S. Jois, Ernawati Sinaga, Teruna J. Siahaan   +5 more
doaj  

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

Journal of Cell Biology, 1991
The ability of carcinomas to invade and to metastasize largely depends on the degree of epithelial differentiation within the tumors, i.e., poorly differentiated being more invasive than well-differentiated carcinomas.
U. Frixen, Jfirgen Behrens, M. Sachs, G. Eberle, B. Voss, Angelika Warda, Dorothea Ltehner, Walter Bircluneier   +7 more
semanticscholar   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8/N‐cadherin pathway

FEBS Open Bio, 2022
Myosin phosphatase target subunit 1 (MYPT1) is a subunit of myosin phosphatase that is capable of regulating smooth muscle contraction. MYPT1 has been reported to be involved in a wide variety of tumours, but its expression and biological functions in ...
Qingling Xie, Ren Liu, Zhihao Zou, Yuanfa Feng, Yiqiao Huang, Guibin Xu, Wei Sun, Yuxiang Liang, Weide Zhong   +8 more
doaj   +1 more source

Image_2_LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer.JPEG

, 2020
Epithelial ovarian cancer (EOC) is the most malignant gynecological carcinoma and is of a high incidence of death due to detection at late stages when metastasis already occurs.
Changhong Liu (519694), Minghua Wu (129689), Buqing Sai (6164186), Jianbo Feng (4098664), Songshu Xiao (8449116), Jia Liu (41593), Liping Li (120326), Yingnan Sun (3532010), Chunhua Zhao (670509), Yan Zhang (8098), Xiaoling She (3532013), Yunchao Li (186024), Shuai Chen (506142), Peiyao Li (230914)   +13 more
core   +1 more source

Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer [PDF]

, 1999
Little is known about the relative contributions of genetic and environmental factors to the development of gastric cancer. Mutations in the cell adhesion molecule E-cadherin are recognized to be associated with the development of undifferentiated ...
S Bevan, Houlston, RS, Peto, J, Cunningham, D, J Peto, Stone, J, N Rahman, R S Houlston, Marossy, A, A Marossy, A Hill, Rahman, N, Bevan, S, Hill, A, J Stone, D Cunningham   +15 more
core   +1 more source