Results 71 to 80 of about 383,770 (381)

Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. [PDF]

, 2014
Tumor invasion and metastases represent a complex series of molecular events that portends a poor prognosis. The contribution of inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) of innate immunity function as
Chin, Arnold I, Zhang, Hanwei
core   +7 more sources

Genomic Locus Modulating IOP in the BXD RI Mouse Strains

G3: Genes, Genomes, Genetics, 2018
Intraocular pressure (IOP) is the primary risk factor for developing glaucoma, yet little is known about the contribution of genomic background to IOP regulation.
Rebecca King, Ying Li, Jiaxing Wang, Felix L. Struebing, Eldon E. Geisert   +4 more
doaj   +1 more source

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

Cell Reports, 2022
Summary: The mechanically activated Piezo channel plays a versatile role in conferring mechanosensitivity to various cell types. However, how it incorporates its intrinsic mechanosensitivity and cellular components to effectively sense long-range ...
Jing Wang, Jinghui Jiang, Xuzhong Yang, Gewei Zhou, Li Wang, Bailong Xiao   +5 more
doaj   +1 more source

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]

, 2018
Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria, Bottero, Lisabianca, Carè, Alessandra, Felicetti, Federica, Gulino, Alessandro, Mattia, Gianfranco, Petrini, Marina, Pontecorvi, Giada, Puglisi, Rossella   +8 more
core   +1 more source

CDH17 (cadherin 17, LI cadherin (liver-intestine)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on CDH17 (cadherin 17, LI cadherin (liver-intestine)), with data on DNA, on the protein encoded, and where the gene is implicated.
Rong, Y, Lee, NP, Luk, JM
openaire   +2 more sources

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

Nature Communications, 2018
During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting
Girish R. Kale, Xingbo Yang, J. Philippe, Madhav Mani, P. Lenne, Thomas Lecuit   +5 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

N-cadherin induces partial differentiation of cholinergic presynaptic terminals in heterologous cultures of brainstem neurons and CHO cells

Frontiers in Synaptic Neuroscience, 2012
N-cadherin is a calcium-sensitive cell adhesion molecule commonly expressed at synaptic junctions and contributes to formation and maturation of synaptic contacts.
Richard J Flannery, Juan L Brusés, Juan L Brusés   +2 more
doaj   +1 more source

Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum

eLife, 2022
Cadherins contribute to the organization of nearly all tissues, but the functions of several evolutionarily conserved cadherins, including those of calsyntenins, remain enigmatic.
Zhihui Liu, Man Jiang, Kif Liakath-Ali, Alessandra Sclip, Jaewon Ko, Roger Shen Zhang, Thomas C Südhof   +6 more
doaj   +1 more source

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]

, 2016
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D, Hye Khan, Md Abdul, Imig, John D, Lee, Kin Sing Stephen, Levick, Scott P, Sharma, Amit   +5 more
core   +3 more sources