Results 111 to 120 of about 136,487 (292)

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, EarlyView.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source

Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms

Journal of Toxicology, 2011
Metals have been definitively linked to a number of disease states. Due to the widespread existence of metals in our environment from both natural and anthropogenic sources, understanding the mechanisms of their cellular detoxification is of upmost ...
Ebany J. Martinez-Finley, Michael Aschner   +1 more
doaj   +1 more source

How do nematodes transfer phosphorylcholine to carbohydrates? [PDF]

, 2010
An unusual aspect of the biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate. The attachment appears to play an important role in nematode development and, in some parasitic species, in immunomodulation.
Harnett, W., Houston, K.M., Rzepecka, J.
core   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.

PLoS Biology, 2008
Notch signaling is critical for cell fate decisions during development. Caenorhabditis elegans and vertebrate Notch ligands are more diverse than classical Drosophila Notch ligands, suggesting possible functional complexities.
Hidetoshi Komatsu, Michael Y Chao, Jonah Larkins-Ford, Mark E Corkins, Gerard A Somers, Tim Tucey, Heather M Dionne, Jamie Q White, Khursheed Wani, Mike Boxem, Anne C Hart   +10 more
doaj   +1 more source

Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]

, 2006
Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams, Aliberti, Alphey, Angus Bell, Antony P. Page, Argaet, Banerjee, Banumathy, Belfiore, Bell, Bell, Bell, Berriman, Blumenthal, Blumenthal, Borel, Bozdech, Braun, Bua, Carlton, Chakraborty, Chakraborty, Chappell, Chappell, Cianciotto, Cohen, Colgan, Dao-Thi, Denkers, Dobson, Dolinski, Dornan, Dornan, Dutta, Fischer, Florens, Galat, Galat, Gavigan, Gavigan, Gilleard, Golding, Hacker, Hall, High, Hirtzlin, Hong, Hope, Kamath, Kay, Ke, Khattab, Kiang, Klinkert, Klinkert, Knobloch, Kumar, Kumar, Kumar, Le Roch, Lightowlers, Lorberg, Ma, Ma, Ma, Matsuda, McLauchlan, Mikol, Monaghan, Monaghan, Moro, Osman, Ostoa-Saloma, Oz, Page, Page, Page, Page, Page, Page, Page, Paul Monaghan, Pelle, Pereira, Peterson, Picken, Pratt, Rascher, Reddy, Riggs, Rossi, Shirane, Silverman, Taylor, Tuo, Valle, Wang, Weiwad, Williams, Yarovinsky, Yu, Zorio   +101 more
core   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Cell Reports, 2016
Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan.
Ineke Dhondt, Vladislav A. Petyuk, Huaihan Cai, Lieselot Vandemeulebroucke, Andy Vierstraete, Richard D. Smith, Geert Depuydt, Bart P. Braeckman   +7 more
doaj   +1 more source

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]

, 2015
Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T, Hall, David H, Nguyen, Ken CQ, Rose, Lesilee S, VanGompel, Michael JW   +4 more
core   +2 more sources

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source