Results 131 to 140 of about 1,676,429 (284)

The first RNAi‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Pest Management Science, EarlyView.
The approval of the RNA interference‐based biopesticide Ledprona (Calantha™) in the USA marks a milestone for RNA‐based crop protection. We discuss the regulatory implications for the European Union, highlighting opportunities, challenges, and the need for adapted risk assessment frameworks for RNA‐based plant protection products.
Aline Koch, Gabi Krczal
wiley   +1 more source

Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

iScience
Summary: There are no cures for neurodegenerative protein conformational diseases (PCDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD).
Alyssa C. Walker, Rohan Bhargava, Michael J. Bucher, Yoan M. Argote, Amanda S. Brust, Daniel M. Czyż   +5 more
doaj   +1 more source

Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense. [PDF]

Chem Biodivers
A novel shad egg peptide (EP) significantly extends Caenorhabditis elegans lifespan through a dual antiaging mechanism. EP systematically remodels lipid metabolism to reinforce cell membranes by promoting beneficial fatty acid biosynthesis and suppressing degradation. Simultaneously, its potent antioxidant activity alleviates oxidative damage, shifting
Du J, Liu Q, Wan Z, Sudo N, Xu Y.
europepmc   +2 more sources

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Ethanol: response and mechanisms in Caenorhabditis elegans

, 2011
The aim of this project is to identify behavioural phenotypes associated with ethanol in C. elegans and potential molecular targets for ethanol that underpin an ethanol response. This will be achieved through a multi-lateral approach using bioinformatics,
Ient, Ben
core   +1 more source

Effect of the microbiome on pathogen susceptibility across four Drosophilidae species

Insect Science, EarlyView.
Four Drosophilidae species were used to investigate how variation in the host microbiome influences susceptibility to infection. Microbial composition and abundance differed among species and treatments. The effects of microbiome manipulation on host survival were both species‐ and pathogen‐specific.
Hongbo Sun, Ben Longdon, Ben Raymond
wiley   +1 more source

RNAi‐based functional genomics tools for the beet leafhopper using microinjection and nanoparticle‐based topical spray

Insect Science, EarlyView.
• First demonstration of functional RNAi in the beet leafhopper, Neoaliturus tenellus, using both dsRNA microinjection and star polycation nanoparticle‐mediated topical spray delivery.•Microinjection achieved over 90% knockdown of Gus and Pum3, revealing gene‐specific fitness effects on survival and fecundity in beet leafhopper.•Nanoparticle‐mediated ...
Jinlong Han, Maria Paula Mejia Alonzo, Meihua Cui, Katherine O. Puffer, Anna M. Wolff, Garret M. Miyake, Oliver T. Neher, Vamsi J. Nalam, Punya Nachappa   +8 more
wiley   +1 more source

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans

Integrative Zoology, EarlyView.
Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou   +8 more
wiley   +1 more source