Results 131 to 140 of about 1,050 (185)
The power of many: when genetics met yeasts and high‐throughput
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
The FAR Protein Family of the Nematode Caenorhabditis elegans [PDF]
Antonio Garofalo +9 more
openaire +1 more source
From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez +3 more
wiley +1 more source
Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality
Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert +2 more
wiley +1 more source
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala +4 more
wiley +1 more source
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos +3 more
wiley +1 more source
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci +15 more
wiley +1 more source
Making fish oils in plants: from alpha to omega
Schematic representation of the biosynthetic pathway for the synthesis of omega‐3 long‐chain polyunsaturated fatty acids. The sequential transgene‐encoded activities required to convert endogenous fatty acids to the longer chain polyunsaturated forms of eicosapentaenoic acid and docosahexaenoic acid are shown in red.
Johnathan A. Napier
wiley +1 more source
Hypoxia results in fragmented mitochondria. Whether this fragmentation promotes or prevents cell death is unresolved. Caenorhabditis elegans mutants defective in mitochondrial fission and fusion coupled with a hypoxia resistant Raptor mutant demonstrated that hypoxia‐induced mitochondrial fragmentation occurs without an intact fission machinery and ...
Julien Goldstick +4 more
wiley +1 more source
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar +13 more
wiley +1 more source

