Results 151 to 160 of about 1,050 (185)

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug‐Like Agents Against Angiostrongylus cantonensis

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Cynnamoyl benzylpiperazine was identified as drug‐like derivative of cinnarizine with anthelmintic activity against A. cantonensis. In this work, 15 out of 31 derivatives showed improved anthelmintic activity with increased solubility. A SAR study was carried out to determine the molecular features involved in such effect.
Bruna L. Lemes, Mariana A. Siegl‐Breno, Marina T. Varela, Flavia B. Lopes, Mikaelly K. Silva‐Nunes, Thaiane D. Santos, Lucas Fukui‐Silva, Daniel B. Roquini, Vinicius G. Maltarollo, Josué de Moraes, João Paulo S. Fernandes   +10 more
wiley   +1 more source

An Atypical Aquaporin 1 Derived From Paramecium multimicronucleatum Functions as a Multifunctional Channel That Permeates Water, Glycerol, and Urea

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Although it had been reported that the translation product of the functional aquaporin gene, aqp1, is localized to the contractile vacuole complex of Paramecium multimicronucleatum, the molecules that pass through this channel protein had not been identified. In the present study, we introduced and expressed this protein in Xenopus oocytes and
Masaki Ishida, Shuichi Ueno, Takashi Tominaga, Kurumi Tanaka, Akito Horikawa, Manabu Hori   +5 more
wiley   +1 more source

Phase Separation Drives Pathological Aggregation in Neurodegenerative Diseases: A 15‐Year Bibliometric Landscape (2009–2024)

Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.
This 15‐year bibliometric study (2009–2024) characterizes the global landscape of liquid–liquid phase separation (LLPS) in neurodegenerative diseases. We delineate the field's evolution from fundamental biophysics to clinical translation, emphasizing the liquid‐to‐solid transition of proteins like TDP‐43, tau, and α‐synuclein.
Chanyuan Zhang, Siyao Chen, He Zhao, Yan Wang, Lingyan Zhou, Haixia Fan, Yan Sun   +6 more
wiley   +1 more source

Structure‐informed engineering of plant–microbe interactions

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY This review critically evaluates how structural biology has enabled interface‐informed engineering of plant–microbe interactions, with a clear emphasis on the relative maturity of plant–pathogen research compared with symbiosis engineering. In plant immunity, atomic resolution structures of apoplastic receptors, host targets, and intracellular ...
Gloria Meng‐Hsuan Lin, Tim Lange, Alexander Förderer   +2 more
wiley   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

Caenorhabditis elegans models for protein misfolding diseases

, 2009
openaire   +1 more source

Patterns of protein turnover in aging Caenorhabditis elegans

, 2015
openaire   +1 more source

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Protein database of Caenorhabditis elegans

Journal of Chromatography B, 2003
Whole genome sequencing of the free-living nematode Caenorhabditis elegans is a prominent achievement in genomics and uncovers the existence of enormous known and unknown gene products. Characterization and linking of all gene products are the next challenging theme of biology. Genome-wide researches are already progressing on C. elegans and the fruits
Hiroyuki, Kaji, Toshiaki, Isobe
openaire   +2 more sources

Chaperone-Interacting TPR Proteins in Caenorhabditis elegans

Journal of Molecular Biology, 2013
The ATP-hydrolyzing molecular chaperones Hsc70/Hsp70 and Hsp90 bind a diverse set of tetratricopeptide repeat (TPR)-containing cofactors via their C-terminal peptide motifs IEEVD and MEEVD. These cochaperones contribute to substrate turnover and confer specific activities to the chaperones.
Veronika, Haslbeck, Julia M, Eckl, Christoph J O, Kaiser, Katharina, Papsdorf, Martin, Hessling, Klaus, Richter   +5 more
openaire   +2 more sources