Results 141 to 150 of about 1,050 (185)

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

The Landscape of BRCA1‐Associated Post‐Translational Modifications

Cell Biology International, Volume 50, Issue 7, July 2026.
ABSTRACT The BRCA1‐BARD1 complex is a vital protein that promotes homologous recombination, acting through its E3 ubiquitin ligase activity. Although ubiquitination remains its only confirmed enzymatic function, emerging evidence suggests that the complex influences a broad range of post‐translational modifications (PTMs), including methylation ...
Nethma Hewa Waduge, Junhua Xiao, Gregory M. Davis   +2 more
wiley   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, Volume 255, Issue 7, Page 671-697, July 2026.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

Soybean‐Derived Exosome‐Like Nanovesicles Regulate Lipid Metabolism via Mitochondrial Biogenesis and UCP1/PGC‐1α Mediated Thermogenesis

Food Frontiers, Volume 7, Issue 4, July 2026.
Soybean‐derived exosome‐like nanovesicles suppress lipid accumulation of adipocytes via UCP1/PGC‐1α mediated thermogenesis pathway and boosting mitochondrial function. ABSTRACT Obesity has become an important public health concern in modern society. Plant‐derived exosome‐like nanovesicles are emerging as candidates for obesity intervention.
Zhenzhu Zhu, Luyuan Ni, Mingwei Gao, Qian Yang, Changli Zhang, Qin Liu   +5 more
wiley   +1 more source

Food and Medicinal Homologous Substances in Sleep Disorders Improvement: Current Advances and Future Perspectives

Food Frontiers, Volume 7, Issue 4, July 2026.
The schematic diagram illustrating the improvement mechanisms of six typical FMH substances and their main active ingredients in different sleep disorders. ABSTRACT Sleep integrates many brain and peripheral processes, profoundly influencing well‐being.
Wenjing Wen, Qili Li, Chenghao Lv, Jing Wen, Yihan Zhang, Yuhang Yi, Tao Li, Fang Wang, Yibo Luo, Si Qin   +9 more
wiley   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Proteostasis Rebalancing by LET‐607 Deficiency Promotes Longevity

Aging Cell, Volume 25, Issue 7, July 2026.
LET‐607 enforces a trade‐off between UPRER and UPRcyto in C. elegans, maintaining a proteostatic balance optimized for development but suboptimal for longevity. LET‐607 deficiency suppresses UPRER but activates UPRcyto via attenuation of one‐carbon metabolism and H3K9 methylation, thereby enhancing cytosolic proteostasis and extending lifespan ...
Haixiang Tong, Wei Li, Pangui Yuan, Feng Li, Qin Liu, Shanshan Pang, Haiqing Tang   +6 more
wiley   +1 more source

Suppression of Ciliogenesis Alleviates Cellular Senescence via AKT Signaling in Gingival Aging

Aging Cell, Volume 25, Issue 7, July 2026.
In human gingival aging, aged gingival fibroblasts show increased senescence with enhanced primary cilia formation. Targeting cilia formation by knocking down IFT88 could reverse fibroblast senescence via the AKT signaling and alleviate periodontal inflammation.
Wenjun Shao, Huihui Yang, Chenghu Yin, Yunjie Zhang, Yixing Xu, Wakam Chang, Haibin Xia, Min Wang, Liangliang Fu, Kaiyao Huang   +9 more
wiley   +1 more source

Circular RNAs–Stress Granule Interplay Drives Aging‐Related Proteostasis Loss

Aging Cell, Volume 25, Issue 7, July 2026.
Ribonuclease K (RNASEK) maintains ribostasis by degrading circular RNAs (circRNAs) in young cells, enabling functional stress granules (SG) and proper RNA‐protein metabolism for healthy aging and longevity. In aged cells, reduced RNASEK activity causes circRNA accumulation in SG, disrupting ribostasis and proteostasis, leading to cellular dysfunction ...
José M. Izquierdo
wiley   +1 more source