Results 131 to 140 of about 136,487 (292)
Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
Experimental and Molecular MedicineThe cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions,
D. Lugano +3 more
doaj +1 more source
The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development [PDF]
, 1994 During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-
Huang, Linda S. +2 more
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The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Developmental Dynamics, EarlyView.Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
Environmental Toxicology and Chemistry, EarlyView.Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff +2 more
wiley +1 more source
Prohibitin Homology Domain Proteins in Caenorhabditis elegans
, 2010 The PHB-d protein family is an evolutionarily ancient family of integral membrane proteins with members in all taxa that are involved in a wide variety of biological process but share several common molecular properties: oligomerization, detergent resistant membrane (DRM) association, and regulation of other proteins.
openaire +2 more sources
Food Safety and Health, EarlyView.This comprehensive guide for the Agilent Seahorse XF HS Mini‐platform presents real‐time analysis of cellular energy metabolism across the mitochondrial stress test, glycolytic rate assay, and real‐time ATP rate assay, with applications in food safety and health and in metabolic disease.
Zhihao Liu +3 more
wiley +1 more source
Food Safety and Health, EarlyView.This study shows the protective effects of potential probiotic strain of Pediococci strains against diarrheal Escherichia coli strains in Caenorhabditis elegans model system. The E. coli strains resulted in severe morphological and physiological damage to the worm whereas the probiotic interventions were able to reduce these damages.
Gunjan Sadera +4 more
wiley +1 more source
iScienceSummary: There are no cures for neurodegenerative protein conformational diseases (PCDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD).
Alyssa C. Walker +5 more
doaj +1 more source
Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments. [PDF]
, 2011 Sensory cilia are assembled and maintained by kinesin-2-dependent intraflagellar transport (IFT). We investigated whether two Caenorhabditis elegans α- and β-tubulin isotypes, identified through mutants that lack their cilium distal segments, are ...
Acar, Seyda +8 more
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