Results 71 to 80 of about 136,487 (292)

Copper Homeostasis in the Model Organism C. elegans

Cells
Cellular and organismic copper (Cu) homeostasis is regulated by Cu transporters and Cu chaperones to ensure the controlled uptake, distribution and export of Cu ions.
Verena Alexia Ohse, Lars-Oliver Klotz, Josephine Priebs   +2 more
doaj   +1 more source

Hsp-90 and the biology of nematodes [PDF]

, 2009
BACKGROUND: Hsp-90 from the free-living nematode Caenorhabditis elegans is unique in that it fails to bind to the specific Hsp-90 inhibitor, geldanamycin (GA).
Devaney, E., Emes, R.D., Gillan, V., Him, N.A.I.I.N., Maitland, K.   +4 more
core   +3 more sources

High resolution map of Caenorhabditis elegans gap junction proteins [PDF]

Developmental Dynamics, 2009
AbstractThe innexin family of gap junction proteins has 25 members in Caenorhabditis elegans. Here, we describe the first high‐resolution expression map of all members through analysis of live worms transformed with green fluorescent protein under the control of entire promoter regions.
Zeynep F, Altun, Bojun, Chen, Zhao-Weng, Wang, David H, Hall   +3 more
openaire   +3 more sources

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

Disease Models & Mechanisms, 2014
Caenorhabditis elegans has a number of distinct advantages that are useful for understanding the basis for cellular and organismal dysfunction underlying age-associated diseases of protein misfolding.
Carmen I. Nussbaum-Krammer, Richard I. Morimoto   +1 more
doaj   +1 more source

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans [PDF]

, 2018
Background: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic
Artal Sanz, Marta, Askjaer, Peter, Baumeister, Ralf, Erinjeri, Annmary Paul, González Hernández, Sara, Hernando Rodríguez, Blanca, Millar, Val, Muñoz, Manuel J., Olmedo López, María, Rodríguez Palero, María Jesús, Schulze, Bettina   +10 more
core   +1 more source

Nicotine affects protein complex rearrangement in Caenorhabditis elegans cells [PDF]

Drug and Chemical Toxicology, 2016
AbstractNicotine may affect cell function by rearranging protein complexes. We aimed to determine nicotine-induced alterations of protein complexes inCaenorhabditis eleganscells, thereby revealing links between nicotine exposure and protein complex modulation.
Sobkowiak, Robert, Zielezinski, Andrzej, Karlowski, Wojciech M., Lesicki, Andrzej   +3 more
openaire   +2 more sources

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

The Caenorhabditis elegans proteome response to two protective Pseudomonas symbionts

mBio
The Caenorhabditis elegans natural microbiota isolates Pseudomonas lurida MYb11 and Pseudomonas fluorescens MYb115 protect the host against pathogens through distinct mechanisms. While P.
Barbara Pees, Lena Peters, Christian Treitz, Inga K. Hamerich, Kohar A. B. Kissoyan, Andreas Tholey, Katja Dierking   +6 more
doaj   +1 more source