Results 91 to 100 of about 1,197 (161)

High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of these ...
Rolf Billeskov, Thomas Lindenstrøm, Joshua Woodworth, Cristina Vilaplana, Pere-Joan Cardona, Joseph P. Cassidy, Rasmus Mortensen, Else Marie Agger, Peter Andersen   +8 more
doaj   +1 more source

Engineering synthetic vaccines using cues from natural immunity [PDF]

, 2013
Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or ...
Irvine, Darrell J, Swartz, Melody A., Szeto, Gregory   +2 more
core   +2 more sources

New approaches to the development of liposomal viral vaccines [PDF]

, 2014
Ліпосомальні технології доставки вакцини в даний час переживають своє нове відродження. Ліпосоми (везикули з фосфоліпідного бішару) є універсальними і надійними системами доставки антигенів для індукції антитіл і Т- лімфоцитів.
Волянський, А.Ю., Давидова, Т.В.   +1 more
core  

Optimized protocol for the detection of multifunctional epitope-specific CD4+ T cells combining MHC-II tetramer and intracellular cytokine staining technologies [PDF]

, 2019
Analysis of multifunctional CD4+ T cells is fundamental for characterizing the immune responses to vaccination or infection. Major histocompatibility complex (MHC)/peptide tetramers represent a powerful technology for the detection of antigen-specific T ...
Carraro, Monica, Ciabattini, Annalisa, Medaglini, Donata, Nolfi, Emanuele, Pastore, Gabiria, Pettini, Elena   +5 more
core   +1 more source

Lactobacillus plantarum producing a Chlamydia trachomatis antigen induces a specific IgA response after mucosal booster immunization.

PLoS ONE, 2017
Mucosal immunity is important for the protection against a wide variety of pathogens. Traditional vaccines administered via parenteral routes induce strong systemic immunity, but they often fail to generate mucosal IgA.
Katarzyna Kuczkowska, Ine Myrbråten, Lise Øverland, Vincent G H Eijsink, Frank Follmann, Geir Mathiesen, Jes Dietrich   +6 more
doaj   +1 more source

An investigation of trachoma vaccine regimens by the chlamydia vaccine CTH522 administered with cationic liposomes in healthy adults (CHLM-02): a phase 1, double-blind trial [PDF]

Background There is no vaccine against the major global pathogen Chlamydia trachomatis; its different serovars cause trachoma in the eye or chlamydia in the genital tract.
Amini, Fahimah, Andersen, Peter L, Bang, Peter, Borges, Álvaro H, Cheeseman, Hannah M, Cole, Tom, Day, Suzanne, Dietrich, Jes, Dohn, Rebecca B, Evans, Abbey, Follmann, Frank, Jensen, Charlotte G, Joypooranachandran, Jennifer, Kristiansen, Max P, Lemm, Nana-Marie, McFarlane, Leon R, Olsen, Anja W, Pollock, Katrina M, Rosenkrands, Ida, Schmidt, Kirstine L, Schronce, Joanna, Shattock, Robin J, Skallerup, Per, Søndergaard, Rie E   +23 more
core   +2 more sources

Liposome-based cationic adjuvant CAF01 enhances the protection conferred by a commercial inactivated influenza vaccine in ferrets

, 2009
Objectives: To assess the effect of CAF01 adjuvant associated to a commercial trivalent inactivated influenza vaccine in the ferret model. Methods:  Ferrets were vaccinated with a range of doses of Sanofi-Pasteur's Vaxigrip with or without the CAF01 adjuvant, and challenged with either one of two H1N1 influenza A virus strains.
Martel, Cyril Jean-Marie, Agger, Else Marie, Jensen, Trine Hammer, Nielsen, Lars Peter, Blixenkrone-Møller, Merete, Andersen, Peter, Aasted, Bent   +6 more
openaire   +1 more source

Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge. [PDF]

Sci Rep, 2023
Eckhardt E, Schinköthe J, Gischke M, Sehl-Ewert J, Corleis B, Dorhoi A, Teifke J, Albrecht D, Geluk A, Gilleron M, Bastian M.   +10 more
europepmc   +1 more source

Head-to-Head Comparison of Novel Vaccine Technologies Comes with a Minefield of Challenges. [PDF]

Pharmaceutics, 2023
Christensen D.
europepmc   +1 more source

Vaccination Against Tuberculosis: Revamping BCG by Molecular Genetics Guided by Immunology

, 2020
Kaufmann, S.
core   +1 more source