Results 131 to 140 of about 3,475 (164)

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

Inflammation, 2008
Sepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related ...
Ahmet, Tekin, Tevfik, Küçükkartallar, Serdar, Türkyilmaz, Ayhan, Dinckan, Hasan, Esen, Burhan, Ateş, Hüseyin, Yilmaz, Adil, Kartal   +7 more
openaire   +3 more sources

Caffeic Acid Phenethyl Ester (CAPE)

Shock, 2014
Excessive free radical production by immune cells has been linked to cell death and tissue injury during sepsis. Peroxynitrite is a short-lived oxidant and a potent inducer of cell death that has been identified in several pathological conditions. Caffeic acid phenethyl ester (CAPE) is an active component of honeybee products and exhibits antioxidant ...
Mustafa, Kassim, Marzida, Mansor, Tengku Ain, Kamalden, Ina Ismiarti, Shariffuddin, Mohd Shahnaz, Hasan, Gracie, Ong, Shamala Devi, Sekaran, Anwar, Suhaimi, Nazeh, Al-Abd, Kamaruddin Mohd, Yusoff   +9 more
openaire   +2 more sources

Yeast Metabolic Engineering for Biosynthesis of Caffeic Acid-Derived Phenethyl Ester and Phenethyl Amide

ACS Synthetic Biology, 2023
Caffeic acid (CA)-derived phenethyl ester (CAPE) and phenethyl amide (CAPA) are extensively investigated bioactive compounds with therapeutic applications such as antioxidant, anti-inflammatory, and anticarcinogenic properties. To construct microbial cell factories for production of CAPE or CAPA is a promising option given the limitation of natural ...
Zi-Chen Jia, Duo Liu, Hai-Di Ma, Yu-Hui Cui, Hui-Min Li, Xia Li, Ying-Jin Yuan   +6 more
openaire   +2 more sources

Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes

Current Medicinal Chemistry, 2019
Diabetes mellitus is a complex metabolic disease characterized by high blood sugar levels. Different pathogenic processes are involved in the etiology of the disease. Indeed, chronic diabetes hyperglycemia is often associated with severe long-term complications including cardiovascular symptoms, retinopathy, nephropathy, and neuropathy.
PITTALA', Valeria, SALERNO, Loredana, ROMEO, Giuseppe, ACQUAVIVA R, DI GIACOMO, Claudia, SORRENTI, Valeria   +5 more
openaire   +2 more sources

Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro

European Journal of Pharmacology, 2005
Caffeic acid phenethyl ester (CAPE), one of the major components of propolis (honeybee resin), has demonstrated a wide spectrum of activities including suppression of eicosanoids by inhibition of cyclooxygenase-1 and cyclooxygenase-2 enzyme activities.
BORRELLI, FRANCESCA, POSADAS I, CAPASSO, RAFFAELE, AVIELLO, GABRIELLA, ASCIONE V, CAPASSO, FRANCESCO   +5 more
openaire   +3 more sources

Effect of caffeic acid phenethyl ester on corneal neovascularization in rats

Current Eye Research, 2001
Caffeic acid phenethyl ester (CAPE), a biologically active component of propolis from honeybee hives, has potent antiinflammatory and antioxidant properties. We aimed to evaluate the ability of topically applied CAPE in comparison with known steroidal (dexamethasone sodium phosphate) and nonsteroidal (indomethacin) topical agents to reduce corneal ...
Y, Totan, E, Aydin, O, Cekiç, M, Cihan Dağloğlu, M, Borazan, K, Dağlioğlu, A, Gültek   +6 more
openaire   +3 more sources

The effects of caffeic acid phenethyl ester on retina in a diabetic rat model

Cutaneous and Ocular Toxicology, 2021
We aimed to investigate the effect of caffeic acid phenethyl ester (CAPE) on retinal apoptosis and oxidative stress parameters in streptozotocin (STZ) induced diabetic rat model.This study included 3 groups; control, STZ, and STZ + CAPE. The rats in STZ, and STZ + CAPE groups were injected with STZ (35 mg/kg, i.p.) for induction of diabetes. In the STZ 
Alparslan Şahin, Savaş Kaya, Mukadder Baylan   +2 more
openaire   +2 more sources

Effect of caffeic acid phenethyl ester on cartilage in experimental osteoarthritis

Rheumatology International, 2002
Activation of nuclear factor kappa B (NF-kappaBeta) in synovial cells is seen in RA and OA patients. Caffeic acid phenethyl ester (CAPE) is a specific and potent inhibitor of NF-kappaBeta. We aimed to determine the in vivo effects of intra-articular injections of CAPE on cartilage in an experimental rabbit osteoarthritis (OA) model.
Nurzat, Elmali, Irfan, Ayan, Yusuf, Türköz, Bülent, Mizrak, Burak, Germen, Arslan, Bora   +5 more
openaire   +2 more sources

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Hepatopulmonary Syndrome

Inflammation, 2010
The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) on inflammatory and related histopathological changes in the lung and liver in experimental hepatopulmonary syndrome (HPS) model. Forty Sprague Dawley rats were used in this study. The animals were divided into four groups of ten rats each.
Ahmet, Tekin, Serdar, Türkyılmaz, Tevfik, Küçükkartallar, Murat, Cakır, Hüseyin, Yılmaz, Hasan, Esen, Burhan, Ateş, Ilhan, Ciftci, Adil, Kartal   +8 more
openaire   +2 more sources

Low concentrations of caffeic acid phenethyl ester stimulate osteogenesis in vitro

Tissue and Cell, 2021
The aim of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on osteoblast-like cell cultures (SAOS-2).SAOS-2 were exposed to CAPE at 1 nM, 10 nM, 100 nM, 1 μM, and 10 μM. Non-exposed cultures were used as control. The following parameters were assayed: 1) cell viability at 1, 3, and 7 days; 2) alkaline phosphatase (ALP ...
Paulo Henrique Neves Santos, Hebert Lacerda Silva, Elizabeth Ferreira Martinez, Júlio César Joly, Ana Paula Dias Demasi, Larissa Moreira Spinola de Castro Raucci, Lucas Novaes Teixeira   +6 more
openaire   +2 more sources