Results 81 to 90 of about 26,527 (265)

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Clinical Pharmacology &Therapeutics, EarlyView.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat, Haribhau Kangne, Rasmus Jansson‐Löfmark, Jens K. Hertel, Amin Rostami‐Hodjegan, Ida Robertsen, Aleksandra Galetin   +6 more
wiley   +1 more source

Comorbid addictive behaviors in disordered gamblers with psychosis

Brazilian Journal of Psychiatry, 2018
Objective: While it has been shown that disordered gamblers with psychosis are at increased risk for comorbid psychopathology, it is unclear whether this dual-diagnosis population is also at greater risk of problematic engagement with comorbid addictive ...
Hyoun S. Kim, Briana D. Cassetta, David C. Hodgins, Daniel S. McGrath, Lianne M. Tomfohr-Madsen, Hermano Tavares   +5 more
doaj   +1 more source

Intelligent Automation Improved Efficiency in Pharmacovigilance Safety Signal Assessment

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacovigilance is the science involving the detection, assessment, understanding, and prevention of adverse events associated with drugs, biologics, or medical devices. In pharmacovigilance, information that suggests a new potential causal relationship between an intervention and an adverse event is called a safety signal. Following their detection,
Jeffrey Warner, Luis Henrique De Souza Teodoro, Anaclara Prada Jardim, Claudia Albera   +3 more
wiley   +1 more source

Development of the Effects of Caffeine Use Scale: A Pilot Study

JANZSSA, 2015
Caffeine Use Disorder is an emerging model of caffeine abuse as outlined by the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM–5; American Psychiatric Association, 2013).
Annaketurah Ralph
doaj  

Cortical Thickness and Appetite Hormones in Adolescent Obesity and Binge Eating Disorder: A Comparative Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined cortical thickness and appetite‐regulating hormones—neuropeptide Y (NPY) and ghrelin—to better understand the neurobiological mechanisms underlying binge eating disorder (BED) and obesity in adolescence. We compared adolescents with BED and obesity, adolescents with obesity without BED, and healthy controls (HCs),
Serkan Turan, İbrahim Mert Erbaş, Fatma Ceren Sarıoğlu, Berrin Çavuşoğlu, Ezgi Molla, Ali Rıza Şişman, Sevay Alsen Güney, Handan Güleryüz, Ayhan Abacı, Yeşim Öztürk, Aynur Pekcanlar Akay   +10 more
wiley   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

The Health Effect of Psychostimulants: A Literature Review

Pharmaceuticals, 2010
Prevalence of psychostimulant use is high, and raising in several countries. Nicotine is the legal stimulant causing the most important public health impact. Cocaine ranks among the most used illicit substances after cannabis.
Barbara Broers, Thierry Favrod-Coune
doaj   +1 more source

DSM-5 criteria for substance use disorders: recommendations and rationale. [PDF]

, 2013
Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen.
Crowley, Thomas, Hasin, Deborah S, Auriacombe, Marc, Compton, Wilson M, Ling, Walter, Grant, Bridget F, Borges, Guilherme, Budney, Alan, Schuckit, Marc, Petry, Nancy M, O'Brien, Charles P, Bucholz, Kathleen   +11 more
core   +1 more source

Fluorescence Behavior of Water‐Soluble Porphyrins Immobilized on LTA Zeolite and Its Chlorogenic Acid Polyphenol Sensing in Coffee Wastewater

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
During coffee bean and cherry washing, contaminants are released into water, making this process a major source of water pollution. Chlorogenic acid can be efficiently detected using hybrid zeolite–porphyrin materials by measuring fluorescence quenching, achieving detection limits lower than current regulatory thresholds.
João Otávio Donizette Malafatti, Gabriele Magna, Francesco Pizzoli, Fabrizio Caroleo, Cadia D'Ottavi, Williane da Silva Freitas, Ailton José Moreira, Elaine Cristina Paris, Luiz Henrique Capparelli Mattoso, Corrado Di Natale, Roberto Paolesse   +10 more
wiley   +1 more source

Motives for Caffeine Consumption Questionnaire (MCCQ): validity and reliability of Turkish version

Psicologia: Reflexão e Crítica
Objectives The aims of this study are to make the Turkish validity and reliability of the scale that explain why caffeine intake. Additionally, it is crucial to highlight that the adaptation of the scale involved a confirmatory factor analysis (CFA) to ...
Tuğba Küçükkasap, Burcu Uslu
doaj   +1 more source