Results 131 to 140 of about 5,149,759 (252)

Models for calcific aortic valve disease in vivo and in vitro

Cell Regeneration
AbstractCalcific Aortic Valve Disease (CAVD) is prevalent among the elderly as the most common valvular heart disease. Currently, no pharmaceutical interventions can effectively reverse or prevent CAVD, making valve replacement the primary therapeutic recourse.
Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai   +5 more
openaire   +3 more sources

Effect of Competition of Nuclear Receptors in Phosphate-Mediated Ectopic Calcification in Calcific Aortic Valve Disease

Bone calcification is a physiological process where calcium salts are deposited within collagen fibers in bones and teeth in the form of hydroxyapatite crystals.
Merazga , Rim
core  

Refining Residual Ischemic Stroke Risk in Anticoagulated Atrial Fibrillation Using Index Outpatient LA Diameter: The CHA2DS2‐VALa Score

Journal of Cardiovascular Electrophysiology, EarlyView.
In anticoagulated atrial fibrillation, residual ischemic stroke risk persists despite guideline‐directed therapy. In this single‐center cohort, an enlarged index outpatient left atrial diameter independently predicted stroke and improved risk stratification when added to CHA2DS2‐VA (CHA2DS2‐VALa), supporting a simple, clinically implementable ...
Sefa Erdi Ömür, Emin Koyun, Gülşen Genç Tapar, Kayıhan Karaman, Metin Karayakali, Ataç Çelik, Uğur Kulu, Yasin Taşkin   +7 more
wiley   +1 more source

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

Journal of Diabetes Investigation, EarlyView.
Liraglutide reverses hyperglycemia‐induced metabolic reprogramming in vascular smooth muscle cells, restoring mitochondrial function and AMPK/PGC‐1α signaling while suppressing mTOR activation and HIF‐1α accumulation. These changes attenuate extracellular matrix remodeling, reduce atherosclerotic plaque burden, and improve plaque stability in diabetic ...
Kun Zhu, Hanxiu Liu, Ni He, Haoyang Wang, Jing Liu, Qinhu Zhang, Zhongwei Liu   +6 more
wiley   +1 more source

Electrocardiographic Pattern of Left Ventricular Hypertrophy with Strain and Survival in Calcific Aortic Valve Disease

, 2018
Background: The prevalence of electrocardiographic (ECG) patterns of left ventricular (LV) hypertrophy and strain in calcific aortic valve disease has not been extensively evaluated.
Nina Ajmone Marsan (323965), Melissa Leung (4860850), Arnold C. T. Ng (323951), E. Mara Vollema (4906996), Jeroen J. Bax (323963), Victoria Delgado (323950), Edgard A. Prihadi (4906993)   +6 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Knockdown of PARM1 Alleviates Aortic Valve Calcification via the PRKCH-MAPK Signaling Pathway

JACC: Basic to Translational Science
Summary: With the aging of the population, the prevalence of calcific aortic valve disease (CAVD) has increased yearly. However, effective means to delay or even reverse the progression of CAVD are still lacking.
Haochang Hu, PhD, Xian Zhu, MD, Jinyong Chen, PhD, Naifang Cao, PhD, Shuangshuang Yang, MD, Lan Xie, PhD, Wangxing Hu, PhD, Si Cheng, PhD, Juan Fang, MD, Yi Qian, PhD, Dilin Xu, PhD, Ningjing Qian, MD, Dao Zhou, MD, Jin Lu, MD, Hanyi Dai, MD, Junhui Xue, PhD, Wei Zhu, MD, Jian’an Wang, MD, PhD, Xianbao Liu, MD, PhD   +18 more
doaj   +1 more source

Imaging techniques in transcatheter aortic valve replacement

, 2013
Robert A Quaife, Jennifer Dorosz, John C Messenger, Ernesto E Salcedo Division of Cardiology, University of Colorado, Aurora, CO, USA Abstract: Calcific aortic stenosis is now understood as a complex valvular degenerative process sharing many risk ...
Quaife RA, Salcedo EE, Dorosz J, Messenger JC   +3 more
core  

Left Bundle Branch Area Pacing Reverts Electromechanical Window Negativity to a Similar Extent as Biventricular Pacing

Pacing and Clinical Electrophysiology, EarlyView.
BiVP = biventricular pacing; CRT = cardiac resynchronization therapy; EMW = electromechanical window; LBBAP = left bundle branch area pacing; QAoC = Time interval from the onset of the QRS complex to the center of the aortic valve closure artifact; QT = QT interval measured by tangent method.
Florien Klein, Metra Daliry, Karin C. Smits, Edoardo Bressi, Peter M. Deissler, Johan van Koll, Jesse H. J. Rijks, Antonius M. W. van Stipdonk, Rachel M. A. ter Bekke, Domenico Grieco, Chiara Manfuro, Giorgia Spiridigliozzi, Annalisa Casalese, Justin G. L. M. Luermans, Frits W. Prinzen, Roel Meiburg, Leonard M. Rademakers, Kevin Vernooy, Uyên Châu Nguyên   +18 more
wiley   +1 more source

Mechanobiology of cadherin-11 in calcific aortic valve disease

, 2018
Calcific aortic valve disease affects a quarter of those over 65 in the US alone. The only treatment is aortic valve replacement, but this intervention carries with it a high rate of morbidity and mortality and is often a procedure of last resort ...
Bowler, Meghan Allardyce
core