Results 141 to 150 of about 5,149,759 (252)

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Calcific Aortic Valve Disease　― From Mechanism to Treatment ―

Circulation Journal
Calcific aortic valve disease (CAVD) is one of the most prevalent heart valve diseases and is characterized by progressive stiffening and calcification of the aortic valve. For decades, CAVD has been treated with surgical intervention. In recent years, some progress has been made in understanding the pathogenesis of CAVD and the exploration of novel ...
Chen, Yuhe, Jia, Songhao, Zhang, Jiawen, Han, Jie, Zhang, Hongjia, Jiang, Wenjian   +5 more
openaire   +2 more sources

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

The Influence of Aortic Valve Hemodynamics and LVAD on bio-transport processes in Calcific Aortic Valve Disease

, 2021
Data management plan for the grant "The Influence of Aortic Valve Hemodynamics and LVAD on bio-transport processes in Calcific Aortic Valve Disease." One of the most common valvular heart diseases is the development of calcific aortic valve (CAV).
Sadat-Hosseini, Hamid
core  

Necrotic adrenal myelolipoma in a geriatric dog

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract Adrenal myelolipomas are rare in dogs and usually incidental findings. They appear as hyperechoic, heterogeneous masses on ultrasound and fat‑dominant lesions on computed tomography (CT). An 11‑year‑old Spaniel cross presented with a 2‑day history of diarrhoea, vomiting and polyuria/polydipsia.
Heather Durkin, Sophie Aspinall
wiley   +1 more source

Permanent Cardiac Pacing in Children: A 30‐Year Follow‐Up Retrospective Study in a Single Pediatric Asian Center

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
This 30‐year retrospective study of pediatric permanent pacing found acceptable long‐term device complication rates, with epicardial leads used predominantly. Pacing‐induced cardiomyopathy occurred only in children with congenital heart disease, highlighting the need for individualized pacing strategies in this cohort and long‐term echocardiographic ...
Jiahui Charmaine Chan, Dyan Zhewei Zhang, Koh Zhi Xuan, Sreekanthan Sundararaghavan, Jonathan Tze Liang Choo, Kah Leng Ho, Eric Tien Siang Lim, Ju Le Tan, Nurhafizah Binte Abdul Aziz, Wan Ting Chan, Monika Kotecha, Jan Hau Lee, Teng Hong Tan   +12 more
wiley   +1 more source

How to assess aortic stenosis using computed tomography: Current and emerging tools

Romanian Journal of Cardiology
Aortic stenosis (AS) is the most common valvular heart disease characterized by progressive calcific degeneration of the aortic valve leaflets, ultimately leading to severe left ventricular (LV) outflow obstruction.
Botezatu Simona B., Dweck Marc R.
doaj   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, Volume 183, Issue 19, Page 5732-5751, October 2026.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source