Results 111 to 120 of about 5,149,759 (252)

Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets

HGG Advances
Summary: Calcific aortic valve stenosis (CAVS) is the most frequent heart valve disease. Elucidating specific gene expression patterns in the aortic valve could provide new insights for understanding disease pathophysiology.
Pardis Zamani, Ursula Houessou, Hasanga D. Manikpurage, Zhonglin Li, Manel Dahmene, Nathalie Gaudreault, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J. Arsenault, Patrick Mathieu, Yohan Bossé, Sébastien Thériault   +12 more
doaj   +1 more source

Histopathology of calcific aortic valve stenosis

, 2006
Calcific aortic valve stenosis is the most common and increasing heart valve disease in the western world. In the last 30 years, diagnosis and management were revolutionized by the development of cardiac catheterisation, echocardiography, cardiac surgery,
Somers, Pamela, Knaapen, Michiel, Mistiaen, Wilhelm, Samers, Pamela   +3 more
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Histological Analysis of Cryopreserved Venous Allografts Used for Liver Transplantation and Hepato‐Biliary‐Pancreatic Surgery

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Cryopreserved venous allografts, which we pioneered in 1999 for use in living donor liver transplantation and hepato‐biliary‐pancreatic surgery, are widely used and are believed to preserve vascular architecture with minimal anticoagulation or immunosuppression requirements and patency comparable to autologous grafts.
Yusuke Seki, Akihiko Ichida, Sumihito Tamura, Mariko Tanaka, Yoshinori Inagaki, Kyoji Ito, Rihito Nagata, Takuya Hashimoto, Nobuhisa Akamatsu, Tetsuo Ushiku, Kiyoshi Hasegawa   +10 more
wiley   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Observational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease

Frontiers in Endocrinology
BackgroundNon-alcoholic fatty liver disease (NAFLD) has emerged as a predominant driver of chronic liver disease globally and is associated with increased cardiovascular disease morbidity and mortality. However, the association between NAFLD and calcific
Qing-Yun Hao, Yu-Hong Zeng, Ying Lin, Jing-Bin Guo, Shi-Chao Li, Ping-Zhen Yang, Jing-Wei Gao, Ze-Hua Li   +7 more
doaj   +1 more source

Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease

Frontiers in Cardiovascular Medicine, 2019
Calcific aortic valve disease (CAVD) is a complex trait disorder characterized by calcific remodeling of leaflets. Genome-wide association (GWA) study and Mendelian randomization (MR) have highlighted that LPA, which encodes for apolipoprotein(a) [apo(a)]
Patrick Mathieu, Marie-Chloé Boulanger
doaj   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source

Sex-dependent aortic valve pathology in patients with rheumatic heart disease.

PLoS ONE, 2017
BackgroundRheumatic heart disease is an autoimmune disease caused by group A streptococci infection and frequently affects the aortic valve. Sex differences are common in the disease progression, treatment, and outcome. However, little is known about the
Feng Xiao, Rui Zheng, Di Yang, Kejiang Cao, Shijiang Zhang, Bingruo Wu, Yongfeng Shao, Bin Zhou   +7 more
doaj   +1 more source

Management of ketogenic diet therapy in patients with ileostomy: A report of 2 cases

Nutrition in Clinical Practice, EarlyView.
Abstract This case series explores the feasibility and clinical considerations of implementing the ketogenic diet therapy (KDT) for epilepsy management in patients with ileostomies. Two pediatric patients with medication‐resistant epilepsy and ileostomies continued KDT under clinical supervision.
Braden J. Baker, Abigail E. Olbina, Marissa A. Godfrey, Annie E. Graber, Taylor N. Parrish, Sarah Isis R. Delima   +5 more
wiley   +1 more source