Results 101 to 110 of about 525,088 (390)

On the Mechanisms of Calcification.

Experimental Biology and Medicine, 1958
SummarySpecimens of skin, tendon, and cortical bone from the calf were exhaustively demineralized with EDTA at pH 7.4. These tissues were then equilibrated with solutions of varying calcium and phosphorus content. All 3 tissues, presumably because of their collagen content, were able to induce formation of hydroxy apatite crystals from otherwise stable
Basil Strates, William F. Neuman
openaire   +3 more sources

Calcium Signaling and Tissue Calcification.

Cold Spring Harbor Perspectives in Biology, 2019
Calcification is a regulated physiological process occurring in bones and teeth. However, calcification is commonly found in soft tissues in association with aging and in a variety of diseases. Over the last two decades, it has emerged that calcification
D. Proudfoot
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

Frontiers in Cardiovascular Medicine, 2018
Previously considered a degenerative process, cardiovascular calcification is now established as an active process that is regulated in several ways by lipids, phospholipids, and lipoproteins.
Yin Tintut, Yin Tintut, Yin Tintut, Jeffrey J. Hsu, Linda L. Demer, Linda L. Demer, Linda L. Demer   +6 more
doaj   +1 more source

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic [PDF]

, 2018
A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity
Aartsma-Rus, A., Bogdanik, L, Davies, K, De Luca, A, Demonbruen, Ar, Duan, D, Elsey, D, Fukada, Si, Girgenrath, M, Gonzalez, Jp, Gordish-Dressman, H, Grounds, Md, Heydemann, A, Kreibich, A, Lutz, C, Nagaraju, K, Nichols, A, Partridge, T, Passini, M, Pazze, Ld, Sanarica, F, Schnell, Fj, Spencer, M, Spurney, C, van Putten, M, Wells, Dj, Willmann, R, Yokota, T, Young, Cs, Zhong, Z   +29 more
core   +3 more sources

Seasonal photosynthesis, respiration, and calcification of a temperate Maërl bed in southern Portugal [PDF]

, 2020
Rhodolith (maerl) beds are biodiversity hotspots with a worldwide distribution. Maerl is the general term for free-living non-geniculate rhodoliths or coralline red algae. In southern Portugal, maerl beds are mainly composed of Phymatolithon lusitanicum,
Barrote, Isabel, Freitas, Cátia, Santos, Rui, Silva, João, SORDO, LAURA   +4 more
core   +1 more source

Metastatic calcification

Dermatology Online Journal, 2003
Calciphylaxis is a rare, painful, and debilitating disease of widespread metastatic calcification that progresses to ischemic tissue necrosis. It occurs almost exclusively in patients with end-stage renal disease and secondary hyperparathyroidism. Reticulated, violaceous, mottled patches commonly appear on the lower extremities and progress to cordlike
openaire   +4 more sources

Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation

Scientific Reports, 2018
Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular
Anique D. ter Braake, P. Tinnemans, C. Shanahan, J. Hoenderop, J. D. de Baaij   +4 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study

BMC Neurology
Background Calcification is common in advanced atheromatous plaque, but its clinical significance remains unclear. This study aimed to assess the prevalence of plaque calcification in the moderate-to-severe internal carotid artery stenosis and ...
Fengli Fu, Xiaoli Liu, Rui Zhang, Siran Zhang, Jianhua Mao, Yan Li, Shu Wan, Shanhu Xu   +7 more
doaj   +1 more source