Results 111 to 120 of about 525,088 (390)

Lipoprotein(a) as Orchestrator of Calcific Aortic Valve Stenosis

Biomolecules, 2019
Aortic valve stenosis (AVS) is the most prevalent disease in the Western World with exponentially increased incidence with age. If left untreated, the yearly mortality rates increase up to 25%.
Johan G. Schnitzler, Lubna Ali, Anouk G. Groenen, Yannick Kaiser, Jeffrey Kroon   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Lack of evidence does not justify neglect. how can we address unmet medical needs in calciphylaxis [PDF]

, 2016
Calcific uraemic arteriolopathy (CUA), or calciphylaxis, is a rare disease predominantly occurring in comorbidity with dialysis. Due to the very low frequency of CUA, prospective studies on its management are lacking and even anecdotal reports on ...
Brandenburg, Vincent Matthias, Cozzolino, Mario, ERA-EDTA Working Group on CKD-MBD, EUCALNET, Evenepoel, Pieter, Floege, Jürgen, Goldsmith, David, Kramann, Rafael, Massy, Ziad, Mazzaferro, Sandro, Schurgers, Leon J., Sinha, Smeeta, Torregrosa, Vicens, Ureña-Torres, Pablo, Vervloet, Marc   +14 more
core   +1 more source

Imperial strategy of cancer cells through mitochondrial transfer

Molecular Oncology, EarlyView.
Cangkrama et al. demonstrated that cancer cells donate their mitochondria to fibroblasts through mitochondrial transfer, reprogramming them into ‘MitoCAF’. Likewise, our group has identified mitochondrial transfer from cancer cells to tumor infiltrating lymphocytes, resulting in mitochondrial ‘hijack’ and impaired antitumor immunity.
Takamasa Ishino, Yosuke Togashi
wiley   +1 more source

Calcific uraemic arteriolopathy - A mini-review [PDF]

, 2016
Calcific Uraemic Arteriolopathy (CUA) or calciphylaxis, is a thrombotic disorder of skin and subcutaneous tissue which typically presents with painful purpuric nodules that may progress to necrotic ulcers, and is a severe, life-threatening condition. CUA
Agapii, Rodica, Fragoso, Andr?, Jerónimo, Teresa, Mendes, Filipa, Neves, Pedro L, Pimentel, Ana, Rocha, Sofia Couto, Silva, Ana   +7 more
core  

Macroalgae may mitigate ocean acidification effects on mussel calcification by increasing pH and its fluctuations

, 2018
Ocean acidification (OA) is generally assumed to negatively impact calcification rates of marine organisms. At a local scale however, biological activity of macrophytes may generate pH fluctuations with rates of change that are orders of magnitude larger
M. Wahl, Sabrina Schneider Covachã, V. Saderne, C. Hiebenthal, Jens Müller, C. Pansch, Y. Sawall   +6 more
semanticscholar   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming

Redox Biology
Aims: Vascular calcification is strongly linked to the development of major adverse cardiovascular events, but effective treatments are lacking. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an emerging category of oral hypoglycemic drugs that ...
Shaofa Wu, Xiaolin Luo, Yang Chen, Zelan Wang, Xi Liu, Ning Sun, Junyong Zhao, Wenjian Luo, Jiawen Zhang, Xiaoyong Tong, Lan Huang, Chuan Liu, Zhexue Qin   +12 more
doaj   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

The Calcium Carbonate Shell of Emiliania huxleyi Provides Limited Protection Against Viral Infection

Frontiers in Marine Science, 2020
Coccolithophores are an important group of marine phytoplankton which cover themselves with the coccosphere – a shell composed of numerous calcium carbonate (CaCO3) platelets.
Mathias Haunost, Ulf Riebesell, Lennart T. Bach   +2 more
doaj   +1 more source