Results 81 to 90 of about 531,192 (386)

Reconstruction of deglacial sea surface temperatures in the tropical Pacific from selective analysis of a fossil coral [PDF]

, 2005
The Sr/Ca of coral skeletons demonstrates potential as an indicator of sea surface temperatures (SSTs). However, the glacial-interglacial SST ranges predicted from Sr/Ca of fossil corals are usually higher than from other marine proxies.
Allison, N., Ellam, R. M., Finch, A. A., Newville, M., Sutton, S. R., Tudhope, A. W.   +5 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Sinomenine attenuates uremia vascular calcification by miR-143-5p

Scientific Reports
Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. There is no approved therapeutic strategy for the prevention of vascular calcification.
Fengyi Yu, Zhong Peng, Ning Gao, Zixu Tang, Zihao Liao, Song Zhao, Shuzhu Zhong, Gloria Umwiza, Hong Huang, Wei Long, Zhangxiu He   +10 more
doaj   +1 more source

Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque. [PDF]

, 2010
BACKGROUND: Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability.
Boyle, JJ, Chan, CF, Firmin, DN, Gatehouse, P, Keenan, NG, Nielles-Vallespin, S, Pennell, DJ, Sheppard, MN   +7 more
core   +2 more sources

SGK1 induces vascular smooth muscle cell calcification through NF‐&kgr;B signaling

Journal of Clinical Investigation, 2018
&NA; Medial vascular calcification, associated with enhanced mortality in chronic kidney disease (CKD), is fostered by osteo‐/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs).
J. Voelkl, Trang T. D. Luong, R. Tuffaha, K. Musculus, Tilman Auer, Xiaoming Lian, C. Daniel, D. Zickler, B. Boehme, M. Sacherer, B. Metzler, Dietmar Kuhl, M. Gollasch, K. Amann, D. Müller, B. Pieske, F. Lang, I. Alesutan   +17 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Correlation of hs-CRP, NLR and PLR tocardiac valve calcification in maintenance hemodialysis patients

Linchuang shenzangbing zazhi, 2020
Objective To investigate the levels of hypersensitivity C-reaction protein(hs-CRP), neutrophil/lymphocyte ratio(NLR) and platelet lymphocyte ratio(PLR) in patients with maintenance hemodialysis(MHD), and to analyze their correlation with cardiac valve ...
WANG Yun-dan, JIANG Wei-jie
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Characteristics and prognostic values of abdominal aortic branches calcification in hemodialysis patients

Renal Failure
Background Vascular calcification is highly prevalent and associated with mortality in hemodialysis patients. However, extreme splanchnic arterial calcification in calciphylaxis with poor prognosis raises questions regarding the reliability of previous ...
Wen Shi, Xiaotong Xie, Yu Zhao, Yuqiu Liu, Xiaoliang Zhang   +4 more
doaj   +1 more source