Results 81 to 90 of about 372,169 (340)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Myocardial Calcinosis in Chronic Renal Failure

Journal of Radiology Case Reports, 2009
<p>The authors are presenting an 18 year old male with history of end stage renal disease and rejected renal transplant. In his workup echocardiogram and non contract CT of chest revealed diffuse endocardial and myocardial calcifications. Extensive
Ashley Kempf, Maryam Golshan Momeni, farhood saremi   +2 more
doaj   +1 more source

Automatic calcium scoring in low-dose chest CT using deep neural networks with dilated convolutions

, 2018
Heavy smokers undergoing screening with low-dose chest CT are affected by cardiovascular disease as much as by lung cancer. Low-dose chest CT scans acquired in screening enable quantification of atherosclerotic calcifications and thus enable ...
de Jong, Pim A., de Vos, Bob D., Išgum, Ivana, Lessmann, Nikolas, van Ginneken, Bram, Viergever, Max A., Zreik, Majd   +6 more
core   +1 more source

Elicitation and representation of expert knowledge for computer aided diagnosis in mammography [PDF]

, 2004
To study how professional radiologists describe, interpret and make decisions about micro-calcifications in mammograms. The purpose was to develop a model of the radiologists' decision making for use in CADMIUM II, a computerized aid for mammogram ...
Alberdi, E., Lee, R., Taylor, P.
core   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study

BMC Neurology
Background Calcification is common in advanced atheromatous plaque, but its clinical significance remains unclear. This study aimed to assess the prevalence of plaque calcification in the moderate-to-severe internal carotid artery stenosis and ...
Fengli Fu, Xiaoli Liu, Rui Zhang, Siran Zhang, Jianhua Mao, Yan Li, Shu Wan, Shanhu Xu   +7 more
doaj   +1 more source

Transcatheter Aortic Valve Implantation in Dialysis Patients [PDF]

, 2012
Background/Aims: Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option for high-risk patients. However, dialysis patients were excluded from all previous studies.
Baglin A, Braun J, Bryg RJ, Christian Kupatt, Cribier A, Edwards FH, Gerhard Steinbeck, Herzog CA, Iung B, Leon MB, London GM, Lucke JC, Maher ER, Matthias Wessely, Michael Fischereder, Philipp Lange, Rodes-Cabau J, Simon Rau, Smith CR, Stinebaugh J, Straumann E, Tanaka K, Ulf Schönermarck, Urena P, Varadarajan P, Varma R   +25 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Improvement of heart rate recovery after exercise training in older people. [PDF]

, 2005
Twenty-four subjects aged 70 and older were retrospectively selected from our archives and screened for symptoms of cardiovascular disease. Baseline exercise test was negative for myocardial ischemia in all subjects.
De Lorenzo A., DEL FORNO, DOMENICO, Giallauria F., Lucci R., Manakos A., Pilerci F., VIGORITO, CARLO   +6 more
core   +1 more source