Results 111 to 120 of about 51,320 (261)

Efficacy of a multidisciplinary 5‐day headache day‐clinic program: A prospective quasi‐experimental pre–post study in primary headache disorders

Headache: The Journal of Head and Face Pain, EarlyView.
xxxx Abstract Objective To evaluate the effects of a short, structured multimodal day‐clinic program on health‐related quality of life and disability in patients with primary headache disorders. Background Although monoclonal antibodies targeting the calcitonin gene‐related peptide (CGRP) pathway have substantially advanced migraine prophylaxis, a ...
Nadja Fiebig, Luise Bartsch, Christine Klötzer, Josephine Gewand, Johanna Ruhnau, Sebastian Strauß, Uwe Reuter, Robert Fleischmann   +7 more
wiley   +1 more source

Online interest in calcitonin gene‐related peptide‐therapies: An infodemiology study using Google trends

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To evaluate changes in public interest in calcitonin gene‐related peptide therapies associated with major product lifecycle milestones using online search data from the United States and Europe. Background Calcitonin gene‐related peptide therapies have transformed migraine treatment, but the impact of key product lifecycle milestones
Bradley Ong, Jad El Ahdab, Nicolas Thompson, Maithili Bhagat, John Ney, Allison L. Weathers   +5 more
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Clinical efficacy of calcitonin compared to diclofenac sodium in chronic nonspecific low back pain with type I Modic changes: a retrospective study

Journal of Pain Research, 2018
Jiaming Zhou,1,2 Tengshuai Li,1 Liandong Li,1 Yuan Xue1 1Department of Orthopaedics Surgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Graduate School, Tianjin Medical University, Tianjin, People’s ...
Zhou J, Li T, Li L, Xue Y
doaj  

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

The Effects of Early Postnatal Alcohol Exposure on Bone Molecular Composition in a Mouse Model. [PDF]

Alcohol Clin Exp Res (Hoboken)
Early postnatal alcohol exposure was associated with long‐term changes in adult bone molecular composition and increased CTX‐I, indicating persistent effects on skeletal biology. Overlap with gavage‐related changes highlights the need to distinguish alcohol‐specific effects from procedural influences.
Dursun I, Elibol B, Ustaoglu SG.
europepmc   +2 more sources