Results 41 to 50 of about 42,581 (243)

Interferon Gamma, but not Calcitriol Improves the Osteopetrotic Phenotypes in ADO2 Mice [PDF]

, 2015
ADO2 is a heritable osteosclerotic disorder that usually results from heterozygous missense dominant negative mutations in the chloride channel 7 gene (CLCN7).
Acton, Dena, Alam, Imranul, Econs, Michael J., Gerard-O'Riley, Rita L., Gray, Amie K., Reilly, Austin M.   +5 more
core   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Calcitriol enhances pyrazinamide treatment of murine tuberculosis

Chinese Medical Journal, 2019
. Background:. Tuberculosis is a leading cause of morbidity and mortality in humans worldwide. There is an urgent need for new and effective drugs to treat tuberculosis and shorten the duration of tuberculosis therapy.
Jing Zhang, Ming Guo, Zhi-Xiang Huang, Rong Bao, Qian Yu, Ming Dai, Xin Wang, Yan Rao, Peng Lyu   +8 more
doaj   +1 more source

Burosumab in Unidentifiable Tumor-Induced Osteomalacia. [PDF]

Clin Case Rep
ABSTRACT Tumor‐induced osteomalacia (TIO) can be challenging due to underlying tumors being either unresectable or unidentifiable. Burosumab, an anti‐FGF23 monoclonal antibody, has been proven to be effective in treating TIO but is currently not subsidized for this indication in Australia.
Der YS, Chaubey S, Mclean A, Trinh Y, Pember S, Sinha A.   +5 more
europepmc   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with paricalcitol and cinacalcet [PDF]

, 2017
Bone changes related to diabetes have been well stablished, but few strategies have been developed to prevent this growing health problem. In our work, we propose to investigate the effects of calcitriol as well as of a vitamin D analog (paricalcitol ...
Alvarez, Andress, Bergua, Bucking, Chan, Chen, Coyne, Coyne, Coyne, Craig, Cunha, Del Pino-Montes, Devaskar, Elder, Fishbane, Flanagan, Gagnon, Gavaia, Gehling, Goodman, Hamann, Hills, Illien-Junger, Irwin, Jayanarayanan, Jones, Katsumata, Keller, King, Kojima, Kojima, Kojima, Krul-Poel, Lee, Lehner, Lieschke, Lin, Maehata, Moss, Olsen, Pham-Short, Pipino, Pisharath, Pugliese, Rodriguez, Sanguineti, Schutter, Shoben, Sprague, Tsuruta, Tung, Westerfield, Wong, Zhao   +53 more
core   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Relationship between adipose tissue dysfunction, Vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2017
Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood.
BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CAROTTI, Simone, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, Morini, Sergio, VESPASIANI GENTILUCCI, UMBERTO   +7 more
core   +1 more source

Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats

Brain Research Bulletin, 2022
Chemotherapy-induced cognitive impairment such as memory impairment and concentration problems are now extensively recognized as side effects of chemotherapy. These problems reduce the quality of life in patients.
Maryam abdollahzadeh, Hamdollah Panahpour, Safa Ghaheri, Hakimeh Saadati   +3 more
doaj   +1 more source

Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival

Head &Neck, EarlyView.
ABSTRACT Background Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high‐risk thyroid surgeries. Methods Retrospective study of patients undergoing segmental tracheal resection for thyroid cancer at MD Anderson Cancer Center (2005–2024).
Anastasios Maniakas, David C. Wilde, Isabelle Fournier, Emily K. Hyde, Li Xu, Jennifer R. Wang, Neil D. Gross, Erich M. Sturgis, Victoria Banuchi, Naifa L. Busaidy, Maria E. Cabanillas, Priyanka Iyer, Ramona Dadu, Steven G. Waguespack, Mimi I. Hu, G. Brandon Gunn, Michael Kwon, Salmaan Ahmed, Michelle D. Williams, Mark E. Zafereo   +19 more
wiley   +1 more source