Results 181 to 190 of about 737,925 (297)

NECAB family of neuronal calcium-binding proteins in health and disease. [PDF]

Neural Regen Res
Bueno D, Schäfer MKE, Wang S, Schmeisser MJ, Methner A.   +4 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus. [PDF]

Neuroprotection
Parthasarathy A, Hanumanthappa R, Bulbule SR, P C K, Nanjaiah H, G G, B M S, Muniswamy D, Kuramkote Shivanna D.   +8 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Neonatal Brain Injury and Calcium Homeostasis

, 2008
During development, the neonatal brain undergoes a period of synaptogenesis known as the brain growth spurt period. During this time, developing neurons are susceptible to injury due to environmental factors, including agents commonly used in obstetric ...
Lema Tomé, Carla Maria
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Distribution of calcium-binding proteins immunoreactivity in the bottlenose dolphin entorhinal cortex. [PDF]

Front Neuroanat
Graïc JM, Grandis A, Sacchini S, Tagliavia C, Salamanca G, Cozzi B, Bombardi C.   +6 more
europepmc   +1 more source

Structural properties of target binding by profilaggrin A and B domains and other S100 fused-type calcium-binding proteins. [PDF]

J Dermatol Sci, 2020
Hinbest AJ, Kim SR, Eldirany SA, Lomakin IB, Watson J, Ho M, Bunick CG.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Ca^XML: Chemistry-informed machine learning explains mutual changes between protein conformations and calcium ions in calcium-binding proteins using structural and topological features. [PDF]

Protein Sci
Zhang P, Nde J, Eliaz Y, Jennings N, Cieplak P, Cheung MS.   +5 more
europepmc   +1 more source