Scientific Reports, 2021 Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory ...
Beata Tepper +5 more
doaj +1 more source
Epigenetic Regulation of Epidermal Differentiation
Epigenomes, 2021 The epidermis is the outer part of the skin that protects the organism from dehydration and shields from external insults. Epidermal cells, called keratinocytes, undergo a series of morphological and metabolic changes that allow them to establish the ...
Wiesława Leśniak
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Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway
Journal of Neuroinflammation, 2022 Highlights LPS-induced neuroinflammation promotes metabolic reprogramming. Neuroinflammation increased glycolytic flow and lactate release. Inhibitors of different glycolytic reactions prevented the inflammatory response. S100B changes suggest a role for
Adriana Fernanda K. Vizuete +8 more
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Frontiers in Neuroanatomy, 2020 In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper +6 more
doaj +1 more source
Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease [PDF]
International Journal of Molecular Sciences, 2019 Richard Fairless +2 more
exaly +2 more sources
On the calcium‐binding ability of the synthetic evolutionary ancestor of calcium‐binding proteins [PDF]
FEBS Letters, 1978 A number of calcium-binding proteins have a domain structure and the domain primary structures are rather similar. Parvalbumins have three domains, two of them are able to bind calcium [l] . Homology of this kind can be found in troponin C [2] and myosin alkali light chains [3] having four domains.
Maximov, E.E. +2 more
openaire +2 more sources
Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Biomolecules, 2021 Motifs within proteins help us categorize their functions. Intrinsically disordered proteins (IDPs) are rich in short linear motifs, conferring them many different roles.
Estella A. Newcombe +7 more
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Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]
, 2009 In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M. +20 more
core +1 more source
Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration
Current Issues in Molecular Biology, 2022 Neurodegeneration leads to multiple early changes in cognitive, emotional, and social behaviours and ultimately progresses to dementia. The dysregulation of calcium is one of the earliest potentially initiating events in the development of ...
Danton H. O’Day
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Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]
, 2008 BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Najl V Valeyev +19 more
core +1 more source