Fungal genomes: suffering with functional annotation errors
Background The genome sequence data of more than 65985 species are publicly available as of October 2021 within the National Center for Biotechnology Information (NCBI) database alone and additional genome sequences are available in other databases and ...
Tapan Kumar Mohanta, Ahmed Al-Harrasi
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Background Recent studies have shown a significant role of the endocannabinoid system, apelin and S100A6 protein in the regulation of cardiovascular system functioning.
Irena Kasacka +3 more
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Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz +12 more
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Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]
Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Lednev, Igor K. +27 more
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Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina. [PDF]
Calcium binding proteins show stereotypical expression patterns within diverse neuron types across the central nervous system. Here, we provide a characterization of developmental and adult secretagogin-immunolabelled neurons in the zebrafish retina with
Stefanie Dudczig +2 more
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Effect of Calcium Deficiency on Growth and Leaf Acid Soluble Proteins of Tomato [PDF]
The effects of temporary Ca (Ca) calcium deficiency lasting 2, 3, 4 or 5 d were investigated on tomato plants at the 6-leaf stage, grown hydroponically under controlled conditions.
Silvestre, Jérôme +3 more
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Characterization of the S100A1 protein binding site on TRPC6 C-terminus. [PDF]
The transient receptor potential (TRP) protein superfamily consists of seven major groups, among them the "canonical TRP" family. The TRPC proteins are calcium-permeable nonselective cation channels activated after the emptying of intracellular calcium ...
Jan Bily +6 more
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Coarse-Grained Modeling and Molecular Dynamics Simulations of Ca2+-Calmodulin
Calmodulin (CaM) is a calcium-binding protein that transduces signals to downstream proteins through target binding upon calcium binding in a time-dependent manner.
Jules Nde +8 more
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Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Arnoult, Christophe +38 more
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Calmodulin binding proteins and neuroinflammation in multiple neurodegenerative diseases
Calcium dysregulation (“Calcium Hypothesis”) is an early and critical event in Alzheimer’s and other neurodegenerative diseases. Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred ...
Danton H. O’Day, Robert J. Huber
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