Results 41 to 50 of about 770,107 (277)

Zinc Modulation of Neuronal Calcium Sensor Proteins: Three Modes of Interaction with Different Structural Outcomes

Biomolecules, 2022
Neuronal calcium sensors (NCSs) are the family of EF-hand proteins mediating Ca2+-dependent signaling pathways in healthy neurons and neurodegenerative diseases.
Viktoriia E. Baksheeva, Philipp O. Tsvetkov, Arthur O. Zalevsky, Vasiliy I. Vladimirov, Neonila V. Gorokhovets, Dmitry V. Zinchenko, Sergei E. Permyakov, François Devred, Evgeni Yu. Zernii   +8 more
doaj   +1 more source

Kinetic regulation of multi-ligand binding proteins [PDF]

, 2016
Background: Second messengers, such as calcium, regulate the activity of multisite binding proteins in a concentration-dependent manner. For example, calcium binding has been shown to induce conformational transitions in the calcium-dependent protein ...
A Zorba, Aleksandr I. Evstifeev, AN Bazanovas, AV Hill, C Frieden, CB Klee, CR Chillakuri, CR Kissinger, DH Heeley, Diana V. Salakhieva, DS Pearson, DS Pearson, F Friedberg, F Fuchs, F Rusnak, Gavin I. Welsh, GC Faas, GC Faas, GG Rodney, GS Adair, H Almagor, H Bading, H Holzer, H Kawasaki, HE Lu, I Andre, I Andre, I Plaza-Menacho, I Semenov, II Sadreev, Ildar I. Sadreev, IM Klotz, JG McCarron, JM Shifman, JN Weiss, KL Yap, KL Yap, KP Hoeflich, M Canepari, M Maki, M Nishiyama, M Zhang, MA Schumacher, MC Kilhoffer, MI Stefan, Michael Z. Q. Chen, MR Nelson, MR Nelson, Nikolay V. Kotov, NV Kotov, NV Valeyev, NV Valeyev, NV Valeyev, O Minowa, P Aloy, P Cimmperman, PR Cutillas, Q Guo, R Chattopadhyaya, RE Klabunde, S Bhattacharya, S Linse, S Oz, S Ryerson, SJ Lee, SW Vetter, T Zhu, TH Crouch, TR Shaikh, U Kragh-Hansen, UV Nagerl, W Bode, W Yang, WD Stein, XY Wei, Yoshinori Umezawa, Z Grabarek   +76 more
core   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Purification of tropomyosin, paramyosin, actin, tubulin, troponin and kinases for chemiproteomics and its application to different scientific fields. [PDF]

PLoS ONE, 2011
BACKGROUND: p-aminobenzamidine (p-ABA) is used as a ligand in the purification of many serine proteases and in their removal from heterogeneous samples. Moreover, p-ABA has a potent ability to bind Ca(2+)-binding proteins.
Tomas Erban
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Distribution of calcium-binding proteins in the chick visual system

Brazilian Journal of Medical and Biological Research, 1997
The calcium-binding proteins calbindin (CB), calretinin (CR), and parvalbumin (PV) have been extensively studied over the last decade since they appear to be important as buffers of intracellular calcium.
C.P. Pfeiffer, L.R.G. Britto
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Targeting glycolysis for neuroprotection in early LPS-induced neuroinflammation

Brain, Behavior, & Immunity - Health
Neuroinflammation is a pathophysiological feature of numerous neurological and psychiatric disorders. The immune response in the central nervous system, driven by microglia and astrocytes, leads to metabolic reprogramming towards aerobic glycolysis, a ...
Adriana Fernanda K. Vizuete, Fernanda Fróes, Marina Seady, Aline Castro Caurio, Osmar Vieira Ramires Junior, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela T.S. Wyse, Carlos-Alberto Gonçalves   +8 more
doaj   +1 more source