Results 61 to 70 of about 654,231 (380)
Multi-ion conduction bands in a simple model of calcium ion channels [PDF]
Phys. Biol. 10 (2013) 026007, 2012 We report self-consistent Brownian dynamics simulations of a simple electrostatic model of the selectivity filters (SF) of calcium ion channels. They reveal regular structure in the conductance and selectivity as functions of the fixed negative charge Qf at the SF.
arxiv +1 more source
Selection of medication in hospitalised elderly patients with Angina Pectoris [PDF]
, 2004 Objective: To evaluate medication changes in hospitalised elderly patients diagnosed with angina pectoris and to compare the selection of medication with evidence-based treatment guidelines. Design: Review of medical notes and patient interview. Setting:
Cacciottolo, Joseph M. +2 more
core
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Volume staging for arteriovenous malformation SRS treatment using VMAT
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Volume staging involves dividing the target volume into smaller parts and treating each part separately. In this study, the feasibility of volume‐staged stereotactic radiosurgery (VS‐SRS) on a linear accelerator using volumetric modulated arc therapy (VMAT) and a frameless patient positioning system is investigated.
Claudia Mendez, Ermias Gete
wiley +1 more source
Methylglyoxal induces cardiac dysfunction through mechanisms involving altered intracellular calcium handling in the rat heart [PDF]
Chemico-Biological Interactions, 2024, 394, pp.110949Methylglyoxal (MGO) is an endogenous, highly reactive dicarbonyl metabolite generated under hyperglycaemic conditions. MGO plays a role in developing pathophysiological conditions, including diabetic cardiomyopathy. However, the mechanisms involved and the molecular targets of MGO in the heart have not been elucidated.
arxiv +1 more source
FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel [PDF]
, 2001 Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy indicates that dye entry is rapid and via the apical surface.
Gale, J.E. +4 more
core +1 more source
Tubular and cellular localization of the cardiac L-type calcium channel in rat kidney [PDF]
, 2002 Tubular and cellular localization of the cardiac L-type calcium channel in rat kidney.BackgroundThe mRNAs of several types of calcium channels have been identified in intact rat kidney, and L-type calcium channels cause changes in intracellular calcium ...
Cebotaru, Liudmila +7 more
core +1 more source
FEBS Letters, EarlyView.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Purpose The aim of this work was to evaluate the SunCHECK PerFRACTION, the software for in vivo monitoring using EPID images. Materials/Methods First, the PerFRACTION ability to detect errors was investigated simulating two situations: (1) variation of LINAC output and (2) variation of the phantom thickness.
Samuel Ramalho Avelino +3 more
wiley +1 more source
Regulation of Presynaptic Calcium Channels by Synaptic Proteins
Journal of Pharmacological Sciences, 2003 Calcium entry into nerve termini via voltage gated calcium channels is an essential step in neurotransmission. Consequently, second messenger regulation of calcium channel activity modulates synaptic activity.
Gerald W. Zamponi
doaj