Results 111 to 120 of about 293,330 (287)
FEBS Open Bio, EarlyView.Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal +2 more
wiley +1 more source
Journal of Pharmacological Sciences, 2013 Calcium is a ubiquitous intracellular signaling molecule required for initiating and regulating neuronal functions. Ca2+ release from intracellular stores in the endoplasmic reticulum into intracellular spaces via intracellular Ca2+–releasing channels ...
Koji Mizuno +2 more
doaj
FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source
Study of Selectivity and Permeation In Voltage-Gated Ion Channels [PDF]
arXiv, 2012 Ion channels are membrane proteins responsible for an enormous range of biological functions. Ion selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical investigation. A reduced model generates the selectivity of voltage-gated L-type calcium channel under a wide range of ...
arxiv
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Single‐isocenter multitarget (SIMT) radiosurgery has become increasingly popular as advancement in planning and delivery systems have made this approach clinically viable. With targets varying in size and distance from isocenter, SIMT plans are highly complex with dynamic multileaf collimator (MLC) motion.
Hem Moktan +3 more
wiley +1 more source
Neurobiology of Disease, 2004 Prions are transmissible pathogens that cause neurodegenerative diseases, although the mechanisms behind the nervous system dysfunctions are unclear.
Malin K Sandberg +3 more
doaj
Evaluation of the effect of metal stents on dose perturbation in the carbon beam irradiation field
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Propose Carbon ion therapy is indicated for cases in which stents have been inserted, such as bile ducts, but the effect of metal stents on carbon ion therapy is unclear. In this study, the dose perturbation of carbon ion therapy caused by metallic bile duct stents was evaluated by dosimetry. Materials and methods Five different types of metal
Yuya Miyasaka +8 more
wiley +1 more source
Large Deviations of Piecewise-Deterministic-Markov-Processes with Application to Stochastic Calcium Waves [PDF]
arXivWe prove a Large Deviation Principle for Piecewise Deterministic Markov Processes (PDMPs). This is an asymptotic estimate for the probability of a trajectory in the large size limit. Explicit Euler-Lagrange equations are determined for computing optimal first-hitting-time trajectories.
arxiv
Ion Channels, Natural Nanovalves [PDF]
arXiv, 2012 Ion channels are proteins with holes down their middle that control the flow of ions and electric current across otherwise impermeable biological membranes. The flow of sodium, potassium, calcium (divalent), and chloride ions have been central issues in biology for more than a century.
arxiv
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose The dual‐layer multileaf collimator (MLC) in Halcyon adds complexities to the dose calculation process owing to the variability of dosimetric characteristics with leaf motion. Recently, an enhanced leaf model (ELM) was developed to refine the MLC model in the Eclipse treatment planning system. This study investigates the performance of
Ryohei Miyasaka +6 more
wiley +1 more source