Results 111 to 120 of about 503,305 (349)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Intrinsic calcium resonance and its modulation: insights from computational modeling

Frontiers in Computational Neuroscience
Hippocampal neurons generate membrane potential resonance due to specific voltage-gated ion channels, known as resonating conductances, which play crucial physiological roles.
Rahul Kumar Rathour, Hanoch Kaphzan
doaj   +1 more source

GABA\u3csub\u3eB\u3c/sub\u3e Receptors Couple to Gα\u3csub\u3eq\u3c/sub\u3e to Mediate Increases in Voltage-Dependent Calcium Current During Development [PDF]

, 2015
Metabotropic GABAB receptors are known to modulate the activity of voltage-dependent calcium channels. Previously, we have shown that GABAB receptors couple to a non-Gi/o G-protein to enhance calcium influx through L-type calcium channels by activating ...
Karls, Andrew S., Mynlieff, Michelle
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Activation of Calcium Channels

Biophysical Journal, 1984
Activation of Ca channels has been described as a Hodgkin-Huxley process in which the time constants have ratios of two or greater (1, 2, 3) or as a three-state linear sequential process with two very different time constants (4). We examined activation by measuring the turn-on and turn-off of macroscopic Ca currents and the discharge of single Ca ...
Brown, Arthur M., Wilson, David L., Lux, H.Dieter   +2 more
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The mechanism by which potassium causes neurite retraction in lamprey descending neurons in cell culture [PDF]

, 2004
only availableSevere spinal cord injury (SCI) disrupts descending axons from reticulospinal (RS) neurons that project to the spinal cord. In most “higher” vertebrates, including humans, recovery is very minimal due to limited regeneration in the central ...
Le, MyChi, Marsh, Georgia, McClellan, Andrew, Ryna, Sarah, Shotts, Lindsay   +4 more
core  

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain

Acta Neuropathologica Communications, 2019
Perioperative sleep disturbance is a risk factor for persistent pain after surgery. Clinical studies have shown that patients with insufficient sleep before and after surgery experience more intense and long-lasting postoperative pain.
Qi Li, Zi-yu Zhu, Jian Lu, Yu-Chieh Chao, Xiao-xin Zhou, Ying Huang, Xue-mei Chen, Dian-san Su, Wei-feng Yu, Xi-yao Gu   +9 more
doaj   +1 more source

Calcium-permeable ion channels in control of autophagy and cancer

Frontiers in Physiology, 2013
Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis.
Artem eKondratskyi, Maya eYassine, Kateryna eKondratska, Roman eSkryma, Christian eSlomianny, Natalia ePrevarskaya   +5 more
doaj   +1 more source