Results 191 to 200 of about 40,341 (222)
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Complete conformational switching in a calcium ionophore
The Journal of Organic Chemistry, 1994A new, conformationally mobile, ether-amide, calcium ionophore, 1(S,R) ,2(S,R),4(R,S)-4-methyl-1,2-bis((N,N-dipropylcarbamyl)methoxy)cyclohexane, is described. The changes in the conformation of the ionophore were monitored by 1 H and 13 C NMR spectroscopy at room temperature and at low temperature (-90 o C).
Morton Raban +4 more
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Calcium Ionophore Polarizes Ooplasmic Segregation in Ascidian Eggs
Science, 1982Calcium ionophore A23187 promotes ooplasmic segregation and orange crescent formation in eggs of the ascidian Boltenia villosa . When eggs were exposed to a gradient of A23187 the orange crescent was induced to form in the region corresponding to the highest concentration of ionophore. This result is consistent with
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Calcium uptake by myometrial membranes: Effect of A 23187, a calcium ionophore
European Journal of Pharmacology, 1976A subcellular fraction, relatively enriched with plasma membranes, showed an ATP-dependent Ca2+ uptake. The addition of a Ca2+. Other drugs (angiotensin, prostaglandin F2alpha, 5-hydroxytryptamine and cyclic nucleotides) had negligible effects on Ca2+ transport. The preparation appears to transport Ca2+, although binding is negligible.
P K, Rangachari +2 more
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Effects of ‘calcium ionophore’ X537A on frog skeletal muscle
Nature, 1975CALCIUM ions are critically involved in the cholinergic neuromuscular transmission process. Presynaptically, Ca2+ is required in transmitter release1 while postsynaptically, it plays a role in acetylcholine-receptor kinetics2. Furthermore, Ca2+ sets off a chain of physicochemical events which leads to muscle contraction3.
D I, Devore, W L, Nastuk
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Mechanism of action of calcium ionophores on intact cells: ionophore-resistant cells.
Membrane & cell biology, 2000Calcium ionophores are generally assumed to directly facilitate the transport of Ca2+ across the plasma membrane. The ability of Ca2+ ionophores ionomycin and A23187 to increase Ca2+ concentration in the cytosol ([Ca2+]i) in different cells was analyzed in detail using fluorescent Ca2+ probes. In fura-2-loaded cells, the dependence of the level of [Ca2+
E N, Dedkova +2 more
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CELLULAR CYTOTOXICITY INDUCED BY CALCIUM IONOPHORE A23187
1977Publisher Summary This chapter discusses the cellular cytotoxicity induced by calcium ionophore A23187. In a study described in the chapter, human peripheral blood mononuclear cells were isolated by Ficol–Hypaque centrifugation and resuspended in final medium (medium 199, 2% 200 mM l -glutamine, 1% 1 M hepes buffer, 5% heat inactivated fetal calf ...
Richard P. MacDermott, Geoffrey S. Nash
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Platelet Membranes, Eicosanoid Biosynthesis and Putative Endogenous Calcium Ionophores
1985In order to facilitate our understanding of the biochemical events that accompany surface membrane receptor activation, generation of second messengers and the sequence of metabolic events involved in mobilisation of arachidonic acid (AA) from membrane phospholipids; it is important to be able to separate subcellular fractions representative of surface
F, Carey +5 more
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Calcium‐Dependent Irreversible Effect of Ionophore A23187 on Melanophores
Pigment Cell Research, 1987The calcium ionophore, A231187, induces a Ca2+‐dependent movement (dispersion) of melanosomes within skin melanophores of the lizard, Anolis carolinensis, in vitro. The effects of A23187 are irreversible, since after repeated rinsing of the skins in the absence of the ionophore they will always darken in Ringer containing Ca2+ but will immediately ...
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NEW SYNTHETIC CALCIUM‐SELECTIVE IONOPHORES
Annals of the New York Academy of Sciences, 1978Michael J. Umen, A. Scarpa
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