Results 181 to 190 of about 40,341 (222)
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Ionophore A23187, calcium and contractility in frog eggs
Experimental Cell Research, 1974Abstract Ionophore A23187 elicits rapid cortical contractions in frog eggs at 10 −6 M conc. in the presence or complete absence of extracellular calcium. Intracellular EDTA or EGTA inhibits contractility, suggesting the importance of intracellular calcium for the response.
T E, Schroeder, D L, Strickland
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Organic calcium-antagonists and calcium-ionophores.
Arzneimittel-Forschung, 1981Verapamil, suloctidil and other organic calcium-antagonists inhibit calcium translocation from an aqueous medium into a hydrophobic domain medicated by 8-[1-(ethyl-1-carboxy-pyrrole-2)]-4-(2-methylene-4-carboxy-5-methylamino-benzoxazole)-spiro(5,5)hendecan-3,9,11-trimethyl-6,7-dioxane (A23187).
Malaisse, Willy +3 more
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Aggregation of calcium ionophore (A23187) in phospholipid vesicles
Biochemical and Biophysical Research Communications, 1989The circular dichroism studies on calcium ionophore, A23187, incorporated in Dipalmitoyl phosphatidyl choline (DPPC) vesicle showed interesting time dependent changes in the CD spectra. Analysis of the data indicated the possible aggregation of the observed dimeric structure of this molecule in non-polar solvents into a stacked dimeric pore in the ...
Balasubramanian, SV, Easwaran, KRK
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Activation of porcine oocytes with calcium ionophore: Effects of extracellular calcium
Molecular Reproduction and Development, 1999The present study examined the mechanism of A23187-induced activation in pig oocytes, with special reference to the effects of extracellular calcium on oocyte activation. The following endpoints were evaluated: intracellular free calcium concentration ([Ca2+]i), intracellular pH ([pH]i), cortical granule (CG) exocytosis, pronuclear formation, and ...
W H, Wang +6 more
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Inhibition by verapamil of ionophore-mediated calcium translocation
Experientia, 1977Verapamil and other organic calcium-antagonists inhibit the A23187-mediated translocation of calcium from an aqueous into an organic phase.
Malaisse, Willy +2 more
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Calcium ionophore A23187 and lymphocyte activation
1976Publisher Summary This chapter discusses the calcium ionophore and lymphocyte activation. Lymphocyte transformation induced by the mitogenic plant lectins, phytohemagglutinin, and concanavalin A, requires extracellular ionized calcium. These lectins induce prompt increases in Ca2+ uptake.
W.C. GREENE, H.J. WEDNER, C.W. PARKER
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Calcium Ionophore A23187 (Eli Lilly)
Thrombosis and Haemostasis, 1975SummaryThe addition of 0.1 μM ionophore A23187 to washed platelets incubated in citrated saline caused massive release of stored serotonin accompanied by intracellular accumulation of inosine monophosphate, but produced no detectable influx of externally added calcium or abnormal structural alterations. With increasing ionophore concentration there was
E H, Mürer +3 more
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Prostaglandin E1 may Act as a “Calcium Ionophore”
Nature New Biology, 1972MUCH of the pharmacology of the prostaglandins (PG) could be interpreted in terms of their facilitation of the movement of calcium ions into or out of biological membranes1. We have therefore investigated this possibility, taking advantage of the configurational changes and attendant changes in light-scattering which result from the binding of calcium ...
S J, Kirtland, H, Baum
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Calcium ionophore A23187 calcium-dependent cytolytic degranulation in human eosinophils.
The Journal of Immunology, 1985Abstract The divalent cation ionophore A23187 is frequently used for studies of eosinophil degranulation. Nonetheless, the mechanism whereby A23187 induces degranulation in human eosinophils is still unclear. In the present experiments, A23187 caused human eosinophils to release a granule protein, eosinophil-derived neurotoxin (EDN) and ...
T, Fukuda +5 more
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Modifying actions of calcium ionophores on insulin release
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975Beta-Cell-rich pancreatic islets were microdissected from noninbred ob/obmice and exposed to the calcium ionophores X-537A and A-23187. X-537A differed from A-23187 in being a potent insulin secretagogue at non-stimulating glucose concentrations. Both ionophores inhibited the stimulation of insulin release obtained after adding 20 mM glucose to the ...
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