Results 101 to 110 of about 2,340,161 (352)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Preparation of antimicrobial calcium phosphate/protamine composite powders with fluoride ions using octacalcium phosphate

Journal of Materials Science: Materials in Medicine, 2022
Calcium phosphates are key biomaterials in dental treatment and bone regeneration. Biomaterials must exhibit antibacterial properties to prevent microbial infection in implantation frameworks.
Daisuke Koizumi, Kitaru Suzuki, Rie Togawa, Kosuke Yasui, Keishi Iohara, Michiyo Honda, Mamoru Aizawa   +6 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Application of Calcium Phosphate Materials in Dentistry

International Journal of Biomaterials, 2013
Calcium phosphate materials are similar to bone in composition and in having bioactive and osteoconductive properties. Calcium phosphate materials in different forms, as cements, composites, and coatings, are used in many medical and dental applications.
Jabr S. Al-Sanabani, Ahmed A. Madfa, Fadhel A. Al-Sanabani   +2 more
doaj   +1 more source

Dekolagenasi Limbah Tulang Paha Ayam Broiler (Gallus domesticus) oleh Natrium Hidroksida (NaOH) untuk Penentuan Kadar Kalsium (Ca) dan Fosfat (PO4)

Al-Kimia, 2016
This research aims to determine the level of Calcium (Ca) and Phosphate (PO4), and the influence of broilers femur submersion in NaOH toward Calcium (Ca) and Phosphate (PO4) levels.
Sitti Musdalifah, Syamsidar HS, Suriani Suriani   +2 more
doaj   +1 more source

In vitro analysis of urinary stone composition in dual-energy computed tomography [PDF]

, 2018
Purpose: Dual energy computed tomography (DECT) is a new method of computed tomography (CT) imaging, allowing the assessment of not only the object's morphology, but also its composition.
Chrzan, Robert, Gawlas, Wojciech, Stępień, Monika   +2 more
core   +1 more source

Calcium phosphate mineralization is widely applied in crustacean mandibles

Scientific Reports, 2016
Crustaceans, like most mineralized invertebrates, adopted calcium carbonate mineralization for bulk skeleton reinforcement. Here, we show that a major part of the crustacean class Malacostraca (which includes lobsters, crayfishes, prawns and shrimps ...
Shmuel Bentov, E. Aflalo, Jenny Tynyakov, L. Glazer, A. Sagi   +4 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Modification of the zirconia ceramics by different calcium phosphate coatings:comparative study

, 2017
The aim of this study was to characterize different calcium phosphate coatings and evaluate in vitro cell response of these materials to ceramics implants.
Ashrafov, A. H, Bolbasov, E. N., Golovkin, A. S., Kozelskaya, A. I., Mishanin, A. I., Novikov, V. A., Shesterikov, E. V., Tverdokhlebov, S. I., Viknianshchukb, A. N.   +8 more
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